University of California

California Institute of Technology

Slipchip Corporation

Talis Biomedical Corporation

Yu-Hsiang Hsu

Abraham Phillip Lee

Rustem F Ismagilov

Feng Shen

William C Tang

Steven C George

David A Selck

Philip Homewood

Christopher C W Hughes

Stefano Begolo

Liang Li

Stephanie McCalla

Mikhail Karymov

Philip James Homewood

Monica Moya

The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.

Fluidic devices and systems for sample preparation or autonomous analysis

Provided is a process for creating a 3D metabolically active microtissue perfused with living microvessels which have a direct fluidic connection with neighboring microfluidic channels. The process comprises preparing a template comprising a plurality of channels, and creating a network within said channels, said network comprising microfluidic channels, metabolically active living microvessels, and microtissues. The microvessels can sprout from said microvessels and/or form within the microtissue in response to a stimulus applied from said microfluidic channels or stimulus derived from the said tissues. In another embodiment, a device is provided comprising a supportive structure, one or more microfluidic channels, one or more microtissue compartments, and one or more microvessels, whereby the microvessels connect said microfludic channels and microtissue and perfuse the microtissue to deliver fluid from the microfluidic channels to the microtissues.

High-throughput platform comprising microtissues perfused with living microvessels

A device for identifying infection by the malaria parasite includes a microfluidic device having an inlet and an outlet and a diagnostic channel interposed between the inlet and the outlet. The diagnostic channel includes a contact surface and a sample pump configured to pump a RBC-containing sample into the inlet. The contact surface may be at least one of hydrophilic and roughened. Malaria infected RBCs (miRBCs) interact with the contact surface and become immobilized thereon whereas non-infected RBCs continue to flow downstream in the diagnostic channel.

Microfluidic devices and methods for malaria detection

Growing community of inventors

Pasadena, CA, United States of America

Yu-Hsiang Hsu