Government of the United States of America, As Represented by the Secretary of Commerce

Yu-Hsiang Cheng

Sergey V Polyakov

Ivan A Burenkov

A quantum flow cytometer for detecting an analyte with photon-number statistics includes: a flow cytometer that: receives a pump light in a first direction; receives an analyte flow comprising the analyte in a second direction; and produces scattered light from scattering the pump light by the analyte; a single photon detector in optical communication with the flow cytometer and that: receives, in a third direction, the scattered light from the flow cytometer; provides a correlative time-of-arrival waveform comprising photon-number statistics as an amplitude and an integrated area, the integrated area being proportional to a number of photons received by the single photon detector, wherein the first direction, the second direction, and the third direction are arranged at oblique angles.

Quantum flow cytometer

A quantum flow cytometer detects an analyte with photon-number statistics and includes: a flow cytometer that receives a pump light, an analyte and produces scattered light from the analyte; an intensity interferometer that includes a beam splitter and receives the scattered light; splits the scattered light; and single photon detectors that receive the scattered light, such that the beam splitter and the single photon detectors provide photon number statistics that detects the analyte. A process for detecting the analyte with photon-number statistics includes: receiving the pump light; producing, by the analyte, scattered light from scattering the pump light; splitting the scattered light into first scattered light and second scattered light; detecting, by single photon detectors, the first scattered light and second scattered light; producing, by the single photon detectors, detection signals; and subjecting the detection signals to an analyzer to detect the analyte by photon number statistics.

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North Brunswick, NJ, United States of America

Yu-Hsiang Cheng