Rutgers, the State University of New Jersey

Yu Feng

Richard H Ebright

Yon W Ebright

David Degen

Yu Zhang

The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.

Antibacterial agents: salinamide derivatives

The invention provides compounds of formula (I):X-&#x3b1;-Y&#x2003;&#x2003;(I)wherein X, Y, and a have any of the values defined in the specification and salts thereof. The compounds are inhibitors of bacterial RNA polymerase.

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New Brunswick, NJ, United States of America

Yu Feng