National Institutes of Health, a Component of the US Dept. of Health & Human Services

Abide Therapeutics, Inc.

Lundbeck La Jolla Research Center, Inc.

Immusol, Incorporated

Yu Feng

Cheryl A Grice

John J M Wiener

Justin S Cisar

Olivia Delene Weber

Katharine K Duncan

Christopher C Broder

Edward A Berger

Paul E Kennedy

Jack R Barber

Mang Yu

Philip M Murphy

Richard Tritz

Christophe Combadiere

Markley C Leavitt

Ghalib Alkhatib

Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.

Dual MAGL and FAAH inhibitors

The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.

CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection

The susceptibility to human immunodeficiency virus (HIV) infection depends on the cell surface expression of the human CD4 molecule and a human fusion accessory factor associated with HIV infection (CXCR4). CXCR4 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CXCR4 plays an essential role in the membrane fusion step of HIV infection. The establishment of stable cell lines that coexpress human CD4 and CXCR4 provides valuable tools for the continuing research of HIV infection and the development of more effective anti-HIV therapeutics.

Cells expressing both human CD4 and a human fusion accessory factor associated with HIV infection

Methods of inhibiting HIV infection by blocking HIV co-receptor RNA expression are provided. Ribozymes which cleave HIV co-receptor RNA and inhibit HIV infection of cells are also provided. Co-receptor targets include fusin and CKR5.

Methods and compositions for inhibiting HIV infection of cells by

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San Diego, CA, United States of America

Yu Feng