Chang Gung University

Chang Gung Memorial Hospital, Linkou

Yu-Chun Lin

Jiun-Jie Wang

Shu-Hang Ng

Yau-Yau Wai

Yi-Ping Lin

Tsung-Han Chan

Chun-Chieh Wang

Gigin Lin

Chong-Yung Chi

In a method for correlating magnetic resonance images with histological sections, a target tissue of a living animal is embedded in an enclosed matrix of an optical cutting temperature compound to obtain a packaged specimen on a platform oriented in a first guiding plane. The packaged specimen on the platform is subjected to an MRI examination by scanning along imaging planes parallel to the first guiding plane, and then subjected to a frozen sectioning procedure along sectioning planes in parallel with a second guiding plane which is parallel to the first guiding plane.

Method for correlating magnetic resonance images with histological sections

The present invention discloses a method for extracting AIF and an application thereof to DCE-MRI. The method comprises steps: contacting a target tissue with a contrast agent to obtain a plurality of images; using the plurality of images to work out the tissue concentration curve of the contrast agent in each voxel; calculating the purity of the tissue concentration curve of each voxel according to the tissue concentration curves; and extracting the voxel having the highest purity as the optimized arterial location; and extracting the tissue concentration curve of the voxel having the highest purity as the arterial input function. The extracted AIF is applied to a pharmacokinetic model to obtain associated pharmacokinetic parameters. The present invention not only improves the accuracy and reliability of the derived quantitative indexes but also promotes the efficiency of the quantitative analysis.

Method for extracting arterial input function and application thereof to dynamic contrast enhanced magnetic resonance imaging

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Gueishan, Taiwan

Yu-Chun Lin