Ohio State Innovation Foundation

Yu-Chou Tseng

Ching-Shih Chen

Samuel K Kulp

Guido Marcucci

Tanios Bekaii-Saab

Christopher C Coss

Denis Guttridge

In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.

Methods and compositions for the treatment of cancer cachexia

Methods of suppressing cachexia in a mammal with cancer comprising administering HDAC inhibitors are provided. Aspects include methods of administering an HDAC class 1 and 2b inhibitor in an amount effective to substantially maintain the mammal's weight compared to a mammal that does receive the HDAC class 1 and 2b inhibitor.

Methods for suppressing cancer-related cachexia

Growing community of inventors

Columbus, OH, United States of America

Yu-Chou Tseng