California Institute of Technology

University of Southern California

Minipumps, LLC

University of California

City of Hope

University of Louisville Research Foundation, Inc.

Doheny Eye Institute

Other

Ico, Inc.

1co, Inc.

Iris International, Inc.

Umachines, Inc.

Cite of Hope

City of Hope National Medical Center and Beckman Research Institute

Neurorecovery Technologies, Inc.

Yu-Chong Tai

Mark Salman Humayun

Damien Craig Rodger

Jason Shih

Fukang Jiang

Sean Caffey

Changlin Pang

Po-Jui Chen

Nicholas E Scianmarello

Xing Yang

Siyang Zheng

Xuan-Qi Wang

Jun Xie

Mandheerej S Nandra

Bo Lu

Victor Reggie Edgerton

Yury P Gerasimenko

Susan Jill Harkema

Joel W Burdick

Ellis Fan-chuin Meng

Roland R Roy

Claudia A Angeli

Colin A Cook

Charles DeBoer

Charles I Grosjean

Thomas Anthony Desautels

Jonathan Hodes

Po-Ying Li

Amish Desai

Shane S Shahrestani

Henry K Lin

Han-Chieh Chang

Terry D Lee

Harvey L Kasdan

James David Weiland

Richard J Cote

Matthieu Liger

Aubrey M Shapero

Jeffrey Chun-Hui Lin

Qing He

Dongyang Kang

Robert H Grubbs

Ashish Ahuja

Raymond Peck

David R Hinton

Lincoln Vallance Johnson

Sherry T Hikita

Shuyun Wu

Wen Li

Chi-Yuan Shih

Karthik Murali

Ramiro Magalhaes Ribeiro

Yang Liu

Wendian Shi

John F Naber

Robert S Keynton

Nicholas A Terrafranca

Yuman Fong

Douglas J Jackson

Dennis O Clegg

Julian D Kavazov

Yong Xu

Wei Wang

Elias Stanley Greenbaum

Azita Emami

Satoshi Konishi

Jeffrey David Brennan

Chih-Ming Ho

Nanhai G Chen

Tseng-Yang Hsu

Rajat N Agrawal

Atoosa Lotfi

Denny K Miu

Chang Liu

Yangsheng Chen

Ronalee Lo

Tzung Hsiai

Abhinav Agarwal

Ming C Wu

Wolfgang Fink

Saswati Chatterjee

Hyuck Choo

Choonsup Lee

Harvey Lee Kasdan

Stephen L Mayo

Olajire Idowu

Aramais Avakian

Weilong Tang

Armand R Tanguay, Jr

Thomas George

Seiji Aoyagi

Sunghoon Kim

Justin Boland

Fei Yu

Stuart Long

Hossein Ameri

Yoko Mullen

Trent Spencer Wells

Yangshen Chen

Mark S Humayun

Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

Inductive damping brain sensor

Medical diagnostic devices and related methods of use are described in which a sensor coil may be connected with a resistive, inductive, and capacitive (RCL) circuit including a power meter and a frequency counter, and the sensor may be positioned on a chest of a subject. The sensor apparatus may apply an alternating current through the sensor coil. The sensor apparatus may measure parallel resistance values in the sensor coil using the power meter for a time interval while the subject inhales and exhales. The sensor apparatus may record the parallel resistance values. The sensor apparatus may determine a first change in the parallel resistance values by measuring a difference between a crest and a trough of the parallel resistance values, wherein the crest of the parallel resistance value corresponds to the inhale and the trough of the parallel resistance value corresponds to the exhale of the subject's breath.

Eddy current damping respiratory waveform and volume sensor

A two-dimensional lattice or mesh scaffold for therapeutic cell implants is disclosed as well as methods for manufacture and use. The lattice is constructed of crisscrossing capillaries of hydrophobic parylene, such as parylene AF4, that may be coated with a hydrophilic polymer, such as parylene C, for cell adhesion. At each intersection of the crisscross, the intersecting capillaries are internally connected so as to allow oxygen to flow freely within. The walls of the capillaries are thin enough to be permeable to oxygen, on the scale of a micron thick, so that oxygen can flow through the lattice and permeate through the capillary walls. For some implants, cells are sandwiched between two or more lattices, the cells being slightly held apart from aggregation with each other by the lattice holes. The implants may then be surgically implanted within a subject.

Microcapillary mesh oxygen transporter for cell transplantations

Embodiments of the present disclosure are directed to a wearable phototherapy eye device. In an example, phototherapy can be controlled by varying an emission property of light emitted from the wearable phototherapy eye device to a user eye. In particular, the wearable phototherapy eye device includes a light source oriented to emit the light towards the user eye. The wearable phototherapy eye device also includes controls, such as electrical, mechanical, and/or electro-mechanical controls, to vary the emission property of the light based on an emission target associated with a sleep phase.

Controllable ocular phototherapy

An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.

Liquid accommodating intraocular lens with an asymmetric chamber

A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

Method of manufacturing a tear flow measurement device

Methods of using an inductive damping brain sensor

A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.

Contact lens with metered liquid system

A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

Miniature fixed and adjustable flow restrictor for the body

A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.

System, device and method for production of bioproduct including high density cell respirator (HDCR) for intensified production of adeno-associated viruses (AAV) and cell-based production

Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having a spinal cord injury, a brain injury, or a neurological neuromotor disease are described.

High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury

The present invention provides devices for characterizing regions of tissue and methods for using the same. The devices are capable of locating, identifying, and characterizing tissue regions of interest in vivo. In one embodiment, the devices are ultrasound-guided. In one embodiment, the devices use characterize regions of tissue using electrical impedance spectroscopy (EIS) sensors. In one aspect, the devices are useful in predicting plaque rupture, such as by determining the level of oxidized low density lipoprotein (oxLDL) and macrophage/foam cells present in an atheroma. In one aspect, the devices are useful in identifying metabolically active atherosclerotic lesions that are angiographically invisible.

Electrochemical impedance spectroscopy

Tear flow measurement device

A long-lasting, wireless, biocompatible pressure sensor device is integrated within a hydrocephalus shunt, either within the shunt's reservoir/anchor or as an inline or pigtailed connector. When integrated within a typical reservoir, the device can sit within the reservoir's hollow frustum area covered by the resilient silicone dome of the reservoir. When integrated as an inline connector, the device can sit at any point on the peritoneal catheter or ventricular catheter, including between the VP shut's valve and reservoir. The pressure sensor device includes electronics that can be powered wirelessly by a reader held to a patient's scalp, and so no battery may be required. The reader can transmit an ambient, atmospheric pressure reading from outside the skull to the implanted device so that its electronics can calculate a calibrated gauge pressure internally and then relay it to a patient's smart phone.

Implantable intracranial pressure sensor

Growing community of inventors

Pasadena, CA, United States of America

Yu-Chong Tai