Tsinghua University

Yu-Ching Tung

Chung-Cheng Chou

Cheng-Hsien Liu

Long Hsu

Huang-Ming Philip Chen

Jen-Tsan Ashley Chi

Chang-Hung Hsieh

Sung-Yang Wei

Hwan-You Chang

Wei-Chia Chang

Bing-Ying Ho

Yu-Ting Tai

Te-Yu Chao

Mao-Chih Hsieh

A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array and observation module and a drug mixing module. The cell culture array and observation module are used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array and observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array and observation module. The heating system is used for real-time temperature sensing and heating control of the drug combinations on the microfluidic chip to simulate high-temperature drug environment when performing hyperthermic intraperitoneal chemotherapy on the three-dimensional tumor microenvironment.

Drug screening platform simulating hyperthermic intraperitoneal chemotherapy

Growing community of inventors

Taoyuan, Taiwan

Yu-Ching Tung