Development Center for Biotechnology

Yu-Chin Nieh

Yi-Jen Chen

Shih-Hsien Chuang

Chuan-Lung Hsu

Win-Yin Wei

Chia-Cheng Wu

Chao-Pin Lee

An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab&#x2212;(L&#x2212;D), wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.

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Taipei, Taiwan

Yu-Chin Nieh