Academia Sinica

Yu-Chi Chou

Che-Kun James Shen

Tsann-Long Su

An-Suei Yang

Chung-Ming Yu

Hong-Sen Chen

Hwei-Jiung Wang

Yi-Kai Chiu

Chao-Ping Tung

Michael Hsiao

Hung-Ju Hsu

Hung-Pin Peng

Wei-Ying Kuo

Yueh-Liang Tsou

Jhih-Wei Jian

Ing-Chein Chen

Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.

Immunoconjugate and uses thereof

Compounds, pharmaceutical compositions, and methods for treating anemia (&#x3b2;-thalassemia anemia or sickle cell anemia.

Methods and compositions for treating &#x3b2;-thalassemia and sickle cell disease

The present invention provides compounds (such as compounds of formula I-a) that induce &#x3b3; globin expression and pharmaceutical compositions thereof. Such compounds may have beneficial therapeutic effects. Compounds and compositions described herein may be used to treat hemoglobinopathies such as &#x3b2;-thalassemia and sickle cell anemia. 

Growing community of inventors

Taipei, Taiwan

Yu-Chi Chou