Ngm Biopharmaceuticals, Inc.

23Andme, Inc.

Yu Chen

Wenyan Shen

Taruna Arora

Hugo Matern

Betty Chan Li

Kalyani Mondal

Germaine Fuh-Kelly

Yao-ming Huang

Louise Scharf

Wei-Jen Chung

Chingwei Vivian Lee

Erik E Karrer

Krista Maureen McCutcheon

Shouhua Xiao

Tina Thai

Samuel Nalle

Navneet Singh

Cecilia Lay

Jilean Beth Fenaux

Steven J Pitts

Zuoan Yi

Valentine Yeung

Augusta Eleanor Broughton

Germaine G Fuh

Patrick Koenig

Yujie Liu

Ping-Chiao Tsai

I-Ling Chen

Joel Benjamin

Shashank Bharill

Mauro Poggio

Zahra Bahrami Dizicheh

Claus Spitzfaden

Shruti Yadav

The present disclosure provides binding proteins, such as antibodies or binding fragments thereof, that bind beta klotho, including human beta klotho, and methods of their use such as in producing an antibody or binding fragment thereof. The present disclosure also provides vectors and cells comprising polynucleotides encoding antibodies or binding fragments thereof that bind beta klotho, including human beta klotho.

Polynucleotides encoding human beta klotho antibodies or binding fragments thereof and methods of use thereof

The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD96 receptor protein (hu-CD96) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD96. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD96 binding to CD155, including effects arising from CD96 interactions with CD226 and/or TIGIT.

Anti-CD96 antibodies and methods of use thereof

The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD200R1 receptor protein (hu-CD200R1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD200R1. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD200 binding to CD200R1.

Anti-CD200R1 antibodies and methods of use thereof

The present disclosure relates to a ULBP6 binding protein that inhibits the interaction between ULBP6 and NKG2D, and methods of treating cancer with said ULBP6 binding protein.

Anti-ULBP6 antibodies

The present disclosure provides binding proteins, such as antibodies, and binding fragments thereof, that bind beta klotho, including human beta klotho, and exemplary specific sequences of their complementarity determining regions, variable regions, heavy chains, and light chains. The present disclosure also provides method of making the antibody or fragment thereof and methods of their use, including, in activating beta-klotho/FGF receptor complex, inducing FGF19-like and/or FGF21-like signaling, improving glucose and lipid metabolism, and treatment of nonalcoholic steatohepatitis.

Anti-human beta klotho antibody or binding fragment thereof and methods of their use

The present disclosure provides binding proteins, such as antibodies and binding fragments thereof, that bind beta klotho, including human beta klotho, and methods of their use, including in the treatment of nonalcoholic steatohepatitis. The present disclosure also provides exemplary specific sequences of complementarity determining regions, variable regions, heavy chains, and light chains of the antibodies and/or binding fragments thereof.

Methods of treating nonalcoholic steatohepatitis comprising administering an anti-human beta klotho antibody or binding fragment thereof

The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.

Beta klotho-binding proteins

Beta klotho-binding proteins and methods of use thereof

Beta-klotho binding proteins

Beta klotho binding proteins and methods of use thereof

Growing community of inventors

Foster City, CA, United States of America

Yu Chen