Abl Bio Inc.

Prestige Biopharma Pte. Ltd.

Yu Bin Choi

Dong Heon Lee

Kyung Duk Moon

Dong In Kim

Kyung Jae Kang

Eun A Kim

Young Min Kim

Yong Ho Ahn

Sang Kyung Park

Soo Kwang Kim

JinWon Jung

Yong Gyu Son

Hee Jung Jun

Jin Hyung Ahn

Weon Kyoo You

Yang Soon Lee

Jinwon Jung

The present invention relates to a bicistronic expression vector for antibody expression, an animal cell transfected with the expression vector, and a method for producing an antibody including culturing the animal cell, in which the expression vector includes a first expression cassette including 'promoter-UTR-intron-antibody light chain gene-polyA' and a second expression cassette including 'promoter-UTR-intron-antibody heavy chain gene-internal ribosome entry site (IRES)-amplification gene-polyA'. An expression vector capable of expressing a desired antibody with high efficiency can be constructed using the bicistronic expression vector including an intron for antibody expression according to the present invention, and the expression vector can produce the antibody by culturing the transfected animal cell with stability and high efficiency.

Bicistronic expression vector for antibody expression and method for producing antibody using same

The present invention relates to a novel dual-targeting protein comprising: a protein that binds specifically to delta-like ligand 4 (DLL4); and an antibody that binds specifically to vascular endothelial cell growth factor (VEGF).

Dual-targeting protein binding specifically to DLL4 and VEGF and use thereof

The present invention relates to a novel monoclonal antibody that binds specifically to delta-like ligand (DLL4), and more particularly to a monoclonal antibody that binds specifically to human delta-like ligand 4 to effectively inhibit the interaction between delta-like ligand 4 and Notch receptor, a polynucleotide encoding the monoclonal antibody, an expression vector comprising the polynucleotide, a transformant comprising the expression vector, a method for preparing the monoclonal antibody, a pharmaceutical composition for preventing or treating cancer comprising the monoclonal antibody, a composition for diagnosing cancer comprising the monoclonal antibody, a method for diagnosing cancer using the monoclonal antibody, and a pharmaceutical composition for preventing or treating autoimmune disease comprising the monoclonal antibody.

Monoclonal antibody binding specifically to DLL4 and use thereof

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Daejeon, South Korea

Yu Bin Choi