Koken Company, Limited

Kyoto University

Dainichiseika Color & Chemicals Mfg. Co., Ltd.

National Cancer Center

Dainippon Sumitomo Pharma Co., Ltd.

Kaken Pharmaceutical Company, Ltd.

Kyoto Prefectural Public University Corporation

Medical Research and Development Corporation

Advanced Innovation Development Co. Ltd.

Akihiko Sano

Yu Aso

Takahiro Ochiya

Masaaki Terada

Shunji Nagahara

Kimi Honma

Tsutomu Sato

Hiroaki Matsubara

Shigeki Hijikata

Yasuyuki Isono

Satoaki Matoba

Makiko Kono

Masanori Fukushima

The present invention provides a cosmetic shaped product: which is substantially formed with relatively low-molecular-weight hyaluronic acid or a water-soluble salt thereof having a high penetrability into the skin; which is easily soluble to water; and which has satisfactory handling properties, and a method for producing the cosmetic shaped product. There is provided a cosmetic shaped product being a sponge-like shaped body formed with at least one polyanionic polysaccharide of hyaluronic acid and a water-soluble salt thereof each having an average molecular weight of 30,000 or lower, the sponge-like shaped body having a bulk specific gravity of 5 to 500 mg/mL. This cosmetic shaped product can be produced by freeze-drying an aqueous solution having a content of the polyanionic polysaccharide of 0.5 to 30% by mass.

Cosmetic molded article and method for manufacturing same

Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.

Sustained-release pharmaceutical composition

Means for transferring efficiently a desired nucleic acid into a cell is provided. The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.

Method of promoting nucleic acid transfer

A cell cultivation carrier implantable in vivo having independent pore with opening of 100 &#x3bc;m-1000 &#x3bc;m on the surface thereof produced by neutralization&#x2022;gellation of collagen acidic solution, said collagen acidic solution is preliminary prepared by passing through a filter of 10 &#x3bc;m or less pore size by 5-20 mg/mL concentration. Especially, a cell cultivation carrier implantable in vivo having sufficiently self-organized accumulation shape&#x2022;structure obtained by carrying out said neutralization under directionally supplying of alkali.

Cell culture carrier implantable in vivo

Growing community of inventors

Tokyo, Japan

Yu Aso