Riken Corporation

Shimadzu Corporation

Toppan Printing Co., Ltd.

Yozo Ohnishi

Toshihiro Tanaka

Yusuke Nakamura

Masatsugu Hori

Aritoshi Iida

Koichi Ozaki

Nobuhiro Hanafusa

Koretsugu Ogata

Ryuh Konoshita

Masatsugu c/o Dept Of Internal Medicine And Therapeutics Hori

An object of the present invention is to identify a novel single nucleotide polymorphism (SNP) associated with the onset and the advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging an inflammatory disease which comprises detecting at least 1 type of genetic polymorphism existing in at least one gene selected from the group consisting of the LBP-32 gene, the TSBP gene, and the WAP gene.

Method of judging inflammatory disease by using single nucleotide polymorphism

It is intended to easily dispense a minute amount of nonvolatile liquid. In a preferred embodiment, in dispensing of mineral oil (nonvolatile liquid), dispensing is conducted in the condition that the amount of air contained in a tip () is small by aspirating a larger amount of mineral oil () than a single dispensing amount in the tip () of a nozzle ().

Method of dispensing nonvolatile liquid in reaction vessel and reaction vessel processing apparatus

A single nucleotide polymorphism occurring on a leptin receptor gene is analyzed and an inflammatory disease is examined on the basis of the analytical data. Further, a substance capable of changing the interaction between the leptin receptor and galectin-2 is selected to thereby screen a remedy for an inflammatory disease.

Method of examining inflammatory disease and method of screening remedy for inflammatory disease

The object of the present invention is to determine inflammatory diseases such as myocardial infarction by identifying single nucleotide polymorphisms (SNPs) associated with myocardial infarction and utilizing these SNPs. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one gene polymorphism existing in at least one gene selected from the group consisting of a lymphotoxin-&#x3b1; (LT-&#x3b1;) gene, an I Kappa B-like (IKBL) gene, and a BAT1 gene; an oligonucleotide used in said method; a kit for diagnosing an inflammatory disease which comprises said oligonucleotide; and use thereof. The present invention further provides a method for treating an inflammatory disease; and a method for screening for a therapeutic agent for an inflammatory disease.

Method of judging inflammatory disease

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Tokyo, Japan

Yozo Ohnishi