Shionogi Company Limited

Yozo Hori

Mitsuaki Ohtani

Fumihiko Watanabe

Yoshinori Tamura

Kaoru Seno

Hiroshige Tsuzuki

Toshiyuki Kato

Takefumi Gemba

Shingo Furue

A composition for treating or preventing arrhythmia containing as an active ingredient a cPLAinhibitor, for example a compound represented by formula (I):wherein Ris optionally substituted aralkyl or the like; Z is &#x2014;S&#x2014; or the like; Xis &#x2014;(CH)s-N(R)&#x2014;CO&#x2014; (wherein Ris hydrogen atom or the like, s is an integer of 0 to 3) or the like; Xis optionally substituted arylene or the like; Xis a bond or the like; A, B, and E are each independently oxygen atom or sulfur atom; D is hydrogen atom or the like; Yis &#x2014;(CH)mCO&#x2014; (m is an integer of 0 to 3) or the like; Yis optionally substituted aryl or the like.

Composition for treating or preventing arrhythmia

A compound of the formula (I):wherein Ris hydroxy and the like; Ris optionally substituted lower alkyl and the like; Ris hydrogen atom and the like; Ris optionally substituted arylene and the like; Ris &#x2014;C&#x2261;C&#x2014; and the like; Ris optionally substituted naphtyl and the likeits optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.

MMP-12 inhibitors

A method and composition for the treatment and/or prevention of stroke is disclosed using N-heterocyclic glyoxamide compounds having the following general formula:

Method for the treatment of stroke using N-heterocyclic glyoxlyamide compounds

Novel carboxylate derivatives exhibiting phospholipase A.sub.2 inhibitory activity are disclosed, Specifically, the following compounds of the formula and pharmaceutically acceptable salts thereof are disclosed: ##STR1## wherein A is hydroxy, amino, or lower alkylamino; R.sup.1 to R.sup.12 are independently hydrogen, methyl, methoxy, or hydroxy, provided that all of R.sup.1 to R.sup.12 are not hydrogen; G.sup.1 is a single bond, or a group of --(CH.sub.2).sub.x O(CH.sub.2).sub.y -- wherein x and y are independently 0-5; G.sup.2 is a single bond, oxygen, sulfur, carbonyl, etc.; G.sup.3 is alkyl, aryl, or a group of the formula: ##STR2## wherein R.sup.13 and R.sup.14 are independently hydrogen, alkyl, aryl, etc.; or R.sup.13 and R.sup.14 may be taken together with the adjacent nitrogen atom to form a heterocyclic group or a group of the formula: ##STR3## wherein Z is a carbon atom or a nitrogen atom, J, K, and L are independently hydrogen or aryl, etc.; p and q are independently 0, 1, or 2; and n is an integer of 1 to 8.

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Osaka, Japan

Yozo Hori