Shanghai Leado Pharmatech Co. Ltd.

Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd.

Youxin Wang

Juan Yu

Tingting Yin

Zhiliang Chen

Lingling Zhang

Jinxia Lin

Jinxiang Zeng

Qiang Ding

Wenliang Lan

Provided are a compound as represented by formula I, a preparation method therefor, and a hydrochloride crystal form A thereof. The compound as represented by formula I and the hydrochloride crystal form A thereof have excellent inhibitory effects on transient receptor potential (TRP) channels, and have good therapeutic effects on TRP channel-associated diseases.

Preparation method for and crystal form of 3-aryloxy-3-five-membered heteroaryl-propylamine compound

Disclosed are a 3-aryloxyl-3-five-membered heteroaryl propylamine compound and use thereof. Specifically disclosed is a compound or a pharmacologically acceptable salt thereof or a prodrug thereof. The compound has the structure of formula I. The compound or the pharmacologically acceptable salt thereof or the prodrug thereof has excellent inhibition to transient receptor potential (TPR) channel proteins, and has good therapeutic effect on diseases related to the TPR channel proteins.

3-aryloxyl-3-five-membered heteroaryl propylamine compound and use thereof

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Shanghai, China

Youxin Wang