Shiseido Company, Limited

Kyushu University

Yousuke Toujo

Kazuyuki Miyazawa

Taketoshi Kanda

Masayoshi Wada

Kenichi Sakuma

Yukimitsu Suda

Masashi Mita

Osamu Shirota

Kenji Hamase

Chieko Mizumoto

Aya Ohkubo

Hiroshi Kutsuna

Yutaka Ashida

Kiyoshi Zaitsu

An embodiment of the present invention is a separating agent wherein a group represented by a chemical formula of: or a group represented by a chemical formula of: is introduced on a surface thereof.

Separating agent and manufacturing method thereof

A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine.  The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.

Method of modifying surface of material

Disclosed is an evaluation method which can rapidly discriminate a Daohomozygote from a large number of animals produced in a mating experiment between a DAO enzyme deficient mouse and other disease model mice, to rapidly perform a quantitative measurement of the D-amino acids contained in a large number of samples. The invention provides a method for evaluating the effect of a test condition on a mouse tissue, or cultured tissue cells derived from the tissue. The method comprises the steps of: providing a Dao1mouse or the like; exposing the tissue from the Dao1mouse or the like, to the test condition; and analyzing the effect of exposing the tissue from the Dao1mouse or the like, to the test condition.

Evaluation/screening method for diseases associated with D-amino acid utilizing DAO1-/-mouse

A phosphorylcholine group-containing chemical compound represented by the following formula (1): 

Phosphorylcholine group-containing compound and surface modifying agent composed of such compound

A phosphorylcholine group-containing chemical compound represented by the following formula (1).  In this formula, m denotes 2-6 and n denotes 1-4. X, X, and X, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X, X, and Xcan be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group. R is one of the structures in the following formulas (2)-(4) (the chemical compound of formula (1) in the structures of the following formulas (2)-(4) is expressed as A-R&#x2014;B).  In formulas (2)-(4), L is 1-6, P is 1-3. Also a surface modifier consisting of the aforementioned phosphorylcholine group-containing chemical compound, modified powder treated with said surface modifier, a chromatography packing consisting of a modified carrier treated with said surface modifier, a filter treated with said surface modifier, and a glass device treated with said surface modifier.

Phosphorylcholine group containing compound and surface modifying agent composed of such compound

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Yokohama, Japan

Yousuke Toujo