Kissei Pharmaceutical Co., Ltd.

Yousuke Mutai

Nobuhiko Fushimi

Junichi Kobayashi

Hideaki Hirasawa

Fumiya Tanada

Yoshiro Kijima

The present invention is to provide a novel pyrazole derivative, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof. The present invention provides a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof, which has TRPM8 inhibitory effects: wherein ring A is Caryl or the like; X is CRor the like; Rand Rare a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; ring B is Caryl or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; n is 0, 1 or 2. Therefore, the compound represented by the formula (I) of the present invention or a pharmaceutically acceptable salt thereof is useful as an agent for treating or preventing diseases or symptoms caused by hyperexcitability or disorder of afferent neurons.

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Azumino, Japan

Yousuke Mutai