Fujisawa Pharmaceutical Company, Ltd.

Yousuke Katsura

Hisashi Takasugi

Yoshikazu Inoue

Ikuo Ueda

Tetsuo Tomishi

Youichi Shiokawa

Takashi Manabe

Takao Takaya

Kiyoshi Taniguchi

Shigetaka Nishino

Thiazole compounds of formula ##STR1## are provided which have antiulcer activity and H.sub.2 -receptor antagonism, wherein R.sup.2 is lower alkyl or lower alkoxy(lower)alkyl, R.sup.3 is hydrogen, A is methylene and R.sup.1 is lower alkyl.

H.sub.2 -receptor antagonist thiazoles

Furylthiazoles and their use as H.sub.2 - receptor antagonists and

A compound of the formula: ##STR1## wherein R.sup.1 is amino, acylamino, cyclo(lower)alkenylamino having amino and oxo, imido, triazolylamino, benzoisothiazolylamino, wherein each of said heterocyclicamino groups may be substituted by one or more substituent(s) selected from the group consisting of lower alkyl, amino and oxo, 2-cyano-3-lower alkylguanidino, 2-acyl-3-lower alkylguanidino, 2-acylguanidino, (1-lower alkylamino-2-nitrovinyl)amino, hydroxy, halogen, cyano, acyl, benzimidazolylthio, triazolyl substituted with amino, or a group of the formula: ##STR2## in which R.sup.4 is hydrogen, cyano, or acyl, and

Thiazole derivatives, processes for the preparation thereof and

A compound of the formula: ##STR1## wherein R.sup.1 is amino, ureido, lower alkanoylamino, lower alkoxycarbonylamino, lower alkylsulfonylamino, lower alkoxy(lower)alkanoylamino, mono or di or trihalo(lower)alkanoylamino, hydroxy(lower)alkanoylamino, protected hydroxy(lower)alkanoylamino, or a group of the formula: ##STR2## in which R.sup.4 is hydrogen or sulfamoyl, R.sup.5 is amino or lower alkoxy, R.sup.2 is hydrogen, lower alkyl, lower alkoxy(lower)alkyl, di(lower)alkylamino(lower)alkyl, (C.sub.3 -C.sub.7)-cycloalkyl, lower alkenyl or mono or di or trihalo(lower)alkyl; R.sup.3 is hydrogen or lower alkyl; or R.sup.2 and R.sup.3 are linked together to form lower alkylene,

New thiazole derivatives, and pharmaceutical composition comprising the

The invention relates to compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and Q are as described, useful in the treatment of ulcers.

Furylthiazole derivatives, processes for the preparation thereof and

The benzazole compounds of this invention can be represented by the following formula [I]: ##STR1## wherein R.sup.1 is aryl or a heterocyclic group, each of which may have suitable substitutent(s),

Benzazole compounds and pharmaceutical composition comprising the same

This invention provides a benezene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen,

Benzene-fused heterocyclic compound and their use as diuretics

This invention provides a oxothiazolidine compound of the formula: ##STR1## wherein R.sup.1 is acyl;

Oxothiazolidine compound and composition containing same

This invention provides a benzene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy or acylamino,

1,4-Dihydro[1]benzothiopyrano[4,3-c]pyrazole derivatives, compositions

Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric,

A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl, and

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Toyonaka, Japan

Yousuke Katsura