Purdue Research Foundation

Arqule, Inc.

Yousheng Guan

Mark Anthony Ashwell

Ping Ye

Syed M Ali

Rocio Palma

Donald E Bergstrom

Joseph Paul Robinson

Jifeng Liu

Ernest Rowland Blatchley, Iii

Shiyue Fang

Lian-Shin Lin

Dennis Anthony Lyn

Zorana Naunovic

Kathyrn E Ragheb

Gerald J Gregori

Chengyue Shen

Dan Yohannes

Shi-Chung Ng

The present invention relates to quinazolinone compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the quinazolinone compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a quinazolinone compound of the present invention.

Quinazolinone compounds and methods of use thereof

A method for photochemical reactor characterization includes an application of using dyed microspheres exposed to UV irradiation under a collimated-beam system. Particle specific fluorescence intensity measurements are conducted using samples form the collimated beam and flow-through reactor results using flow cytometry. A numerical model may be used to simulate the behavior of the reactor system to provide a particle-tracking algorithm to interrogate the flow and intensity field simulations for purposes of developing a particle specific estimate of the dose delivery. A method for measuring UV dose distribution delivery in photochemical reactors is provided that includes introducing microspheres labeled with a photochemically-active compound in a UV reactor. The labeled microspheres are harvested downstream of the irradiated zone of a UV reactor and exposed to UV irradiation under a collimated beam of UV irradiation. The method further includes quantifying a UV dose-response behavior, conducting fluorescence intensity measurement on the labeled microspheres from the UV reactor, and developing an estimate of a dose distribution delivered by a UV reactor based on the numerical deconvolution of the sum of the UV dose response behavior and fluorescent intensity of exposed microspheres.

Dyed microspheres for characterization of photochemical reactor behavior

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North Billerica, MA, United States of America

Yousheng Guan