University of Texas System

Youseph Yazdi

Jonathan Ophir

Rebecca Rae Richards-Kortum

Michele Follen Mitchell

Gregg Staerkel

A method for detecting tissue abnormality, particularly precancerous cervical tissue, through fluorescence spectroscopy is disclosed. In vitro fluorescence measurements over a variety of different fluorescence spectra are used to screen tissue samples. Using a principal component analysis (PCA), it is possible to discriminate between normal and dysplastic tissues with relatively low false-positive and false-negative results.

Optical method for the detection of cervical neoplasias using

An improved ultrasonic pulse-echo method and apparatus that has particular application in estimating sound velocity in organic tissue is disclosed. The method employs a standard transducer or transducer containing device which is translated transaxially, thereby compressing or displacing a proximal region of a target body in small known increments. At each increment, a pulse is emitted and an echo sequence (A-line) is acquired from regions within the target along the sonic travel path or beam of the transducer. Segments of the echo sequence corresponding to a distal region within the target are selected as a reference to estimate the incremental change in echo arrival time. A plot of these arrival time estimates versus the target compression depth is then generated and a least squares linear fit is made. The slope of the linear fit is c.sup.-1, where c is an estimate of the speed of sound in the target.

Transaxial compression technique for sound velocity estimation

An improved ultrasonic pulse-echo method and apparatus that has particular application in making precision measurements of compressibility in any backscattering material, in particular organic tissue, is disclosed. The method employs a standard transducer or transducer containing device which is translated transaxially, thereby compressing or displacing a proximal region of a target body in small known increments. At each increment, a pulse is emitted and an echo sequence (A-line) is detected from regions within the target along the sonic travel path or beam of the transducer. Resulting time shifts in echo segments corresponding to features in the target provide relative and quantitative information concerning compressibility of the target.

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Houston, TX, United States of America

Youseph Yazdi