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Youngdae Kim

Jungsoo Kim

Keunja Park

Jisoo Kim

The present invention relates to polyoxyethylene-polyoxypropylene (POE-POP) vitamin E, which is prepared from vitamin E by polyethoxylation and polypropoxylation, and a method for preparing the same. The POE-POP vitamin E has a high surface activity and an excellent safety for the skin, so that the POE-POP vitamin E can be advantageously used in the cosmetic industry, the food industry and the medical industry.

Polyoxyethylene-polyoxypropylene vitamin E and process for preparation thereof

Disclosed is polyoxypropylenepolyoxyethylene vitamin E, represented by formula (I). It is prepared by subjecting vitamin E to polyethoxylation and then, to polypropoxylation to a proper extent. The vitamin E is of superior anti-oxidation activity with water solubility. The bent chain of the polyoxypropylenepolyoxyethylene vitamin E increases the cross-sectional area of the whole molecule, making it difficult for the molecule to penetrate into the skin. It is very safe to apply to the skin. The polyoxypropylenepolyoxyethylene vitamin E has superb surface activity by forming close bilayer vesicle structures, like phospholipids or dialkyl surfactants, so it can be advantageously used in the cosmetic industry, the food industry and the medical industry. In said formula, R is &mdash;(OCH CH ) &mdash; wherein m is an integer of 0 to 150; R is (a) wherein n is an integer of 1 to 200; A is (b) or (c); B is &mdash;CH at the 5-, 7- or 8-position of vitamin E; and p is an integer of 1 or 3.

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Youngdae Kim