New York University

Agency for Science, Technology and Research

National University of Singapore

Albert Einstein College of Medicine

Harvard College

Nanyang Technological University

Young-Tae Chang

Nam-Young Kang

Jaeki Min

Malini Olivo

Dinish Unnimadhava Kurup Soudamini Amma

Young-Hoon Ahn

Seong Wook Yun

Duanting Zhai

Seong-Wook Yun

Kaustabh Kumar Maiti

Sung-Jin Park

Gustavo Rosania

Victor L Schuster

Yuling Chi

Kiat Seng Jason Soh

Cheryl Kit Mun Leong

Nam Young Kang

Marc Vendrell Escobar

Qian Li

Sung Chan Lee

Hyung Ho Ha

Stuart L Schreiber

Thomas M Wisniewski

Neville Robert Kallenbach

Liang Yang

Bridget K Wagner

Chunhui Zhou

Zhigang Liu

Kwok Wei Shah

Ming-Yong Han

Michael Christian Givskov

Chit Yaw Fu

Shuhua Liu

Paul A Clemons

Zhi Wei Seh

Yogeswari Chandran

Animesh Samanta

Sahu Srikanta

Kiat Seng Soh

Raj Kumar Das

Jun Cheng Er

Yun Kyung Kim

Hyman A Carrinski

Kit Mun Cheryl Leong

Sung Jin Park

Mui Kee Tang

Shenliang Wang

Alexander Schier

Ho-Sang Moon

Michelle Low

Sung-Chan Lee

Eric Jacobson

Puja Parikh

Fabio Piano

Yun-Mi Jeong

Jaw Wook Lee

Jun-Young Kim

The present invention relates to a family of fluorescent compounds based on the BODIPY scaffold, and methods for the preparation of said compounds. The present invention further relates to the use of said compounds for the detection of bacterial biofilms, wherein the bacterial biofilm comprisesand the compound specifically binds to a Fap protein of, or wherein the compound specifically binds to bacterial cells that contain high levels of cyclic-di-guanosine-monophosphate (c-di-GMP).

Chemical fluorescent probes for detecting biofilms

There is provided a method of preparing a surface enhanced Raman spectroscopy (SERS) particle comprising the step of encapsulating a plurality of Raman molecules on the surface of a metallic core with a biocompatible protective shell at an elevated temperature selected to decrease the encapsulation time by more than one-fold relative to an encapsulation performed at 20&#xb0; C.

Method for preparing a surface enhanced Raman spectroscopy particle

A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes for human serum albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.

Megastokes amino-triazolyl-BODIPY compounds and applications to live neuron staining and human serum albumin FA1 drug site probing

The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of beta cells, pancreatic islets and microglia cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can also differentiate healthy pancreatic islet cells from diabetic pancreatic islet cells. 

Bodipy structure fluorescence probes for diverse biological applications

The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.

Fluorescent cell cycle probe having M-phase specificity

The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line.

Alkylamino BODIPY dyes as selective fluorescent probes for proteins and mouse embryonic stem cells

A compound of structural formula (I): The values and alternative values are as defined herein. The invention also includes biosensors comprising nanoparticles functionalized with a compound of structural formula (I). Also described is a method for labeling a biomolecule using a compound of structural formula (I) and a method of detecting a target biomolecule using a compound of structural formula (I) or a biosensor of the invention.

Development of photostable near-IR cyanine dyes for in vivo imaging

The present invention generally relates to prostaglandin transport. More specifically, the invention is directed to compounds that inhibit prostaglandin transport and subsequent COX-2 induction, and methods relating thereto.

Prostaglandin transporter inhibitors

A compound for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) and a method of forming the compound is provided. The compound has Formula I: wherein W is selected from the group consisting of an optionally substituted aryl group and an optionally substituted heteroaryl group; each Y independently is NRR, wherein Rand Rare independently selected from the group consisting of H and C-Calkyl, or Rand Rcombine to form together with the nitrogen to which they are attached a heterocyclic group with 4 to 5 carbon atoms,is used to denote a single or a double bond, and Z is NH, NH, NH&#x2014;(C&#x2550;O)&#x2014;(CH)&#x2014;SH, wherein n=1 to 10, or or a tautomer or stereoisomer thereof, or a salt thereof. A method and device for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) is also provided.

Surface Enhanced Raman Spectroscopy (SERS) compounds and methods of their preparation

The present invention relates to the use of rosamine derivative compounds, as described herein, in detecting differentiated forms of a cell type of interest in a sample and in screening for compounds which inhibit differentiation of the cell type of interest. The candidate compound has the following structure: 

Combinatorial rosamine library to detect cell-state switching

The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: I or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of neural stem cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can detect and separate neural stem cells without immunostaining, providing a much shorter and more convenient method for detection of neural stem cells. 

BODIPY structure fluorescence dye for neural stem cell probe

The invention includes a compound represented by the following structural formula: wherein is described herein. The compounds of the invention are useful in staining embryonic stem cells. 

Chalcone structure fluorescence dye for embryonic stem cell probe

The present invention relates to methods of detecting, in a sample, embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods include providing a sample potentially containing such cells and providing a rosamine derivative compound of the formula (I): where the rosamine derivative compound selectively produces fluorescent signals for embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods also include the steps of contacting the sample with the rosamine derivative compound and detecting the presence of the embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells based on fluorescent signals emitted by the sample following said contacting.

Methods for detecting embryonic stem cells, induced pluripotent stem cells, or cells undergoing reprogramming to produce induced pluripotent stem cells

The present invention is directed toward benzimidazolium dye compounds of formula (I) as follows: wherein,

Benzimidazolium dyes and their use as fluorescent chemosensors

Provided are methods of inhibiting prostaglandin transporter (PGT) activity in mammals. Also provided are methods of determining whether a test compound is an inhibitor of a prostaglandin transporter. Additionally provided are compounds that inhibit prostaglandin transporter activity, and pharmaceutical compositions of those compounds. Methods of inhibiting COX-2 in a mammal are also provided. Additionally, methods of treating pain or inflammation in a mammal are provided.

Growing community of inventors

Singapore, Singapore

Young-Tae Chang