Development Center for Biotechnology

Dcb-usa LLC

Young-Sun Lin

Ta-Tung Yuan

Yu-Shen Hsu

Chao-Yang Huang

Jiann-Shiun Lai

Chi-Kuan Chen

Tse-Wen Chang

Jim Jinn-Chyuan Sheu

Lee-Hwa Lo

Nien-Yi Chen

This invention relates to a mutantheat-labile enterotoxin (LT) subunit A that can be used as an adjuvant. This subunit A mutant contains an amino acid substitution at a position corresponding to position 61 of a wild-type LT. An LT containing this mutated subunit A exhibits reduced toxicity compared to its wild type counterpart.

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The present invention features a human antibody that specifically binds to human cytomegalovirus (HCMV), its encoding nucleic acid(s), and use of the antibody/nucleic acid(s) in treating HCMV infection.

Anti-human cytomegalovirus antibodies

Provided is an antibody against enterovirus 71 comprising the amino acid sequence shown in SEQ ID NOS: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, or 26 or functionally active homologues thereof. Also provided are methods for obtaining the antibody comprising (a) selecting a yeast expressing such an antibody from a yeast library, (b) culturing the yeast under conditions that the antibody is expressed, and (c) recovering the antibody from the culture. Also provided is a process for producing the antibody comprising (a) culturing a host cell under conditions that the antibody is expressed, (b) recovering the antibody from the culture, wherein the host cells are transformed or transfected for expressing the antibody against enterovirus 71. Also provided are pharmaceutical compositions comprising an antibody against enterovirus 71 and a pharmaceutically acceptable carrier or diluent, wherein the antibody has an anti-virus agent or detectable label attached thereto.

Recombinant enterovirus 71 neutralizing antibodies and applications thereof

Growing community of inventors

Xizhi, Taiwan

Young-Sun Lin