Hanmi Pharm. Co., Ltd.

Young Su Yoon

Jae Hyun Park

Yong Il Kim

Jong Soo Woo

Ho Taek Im

Leedong Roh

Shanmugam Srinivasan

The present invention provides a pharmaceutical composition for the prevention or treatment of cardiovascular disorders containing losartan or a pharmaceutically acceptable salt thereof; amlodipine or a pharmaceutically acceptable salt thereof; a disintegrant; and a coating agent. The composition of the present invention, which has the best combination and optimum ratio of a disintegrant to a coating agent, shows sufficient strength and high dissolution rates under various pH environments, and thus, it is useful for the preparation of an excellent solid formulation exhibiting improved drug delivery efficiency and storage stability.

Solid pharmaceutical composition comprising amlodipine and losartan

Provided is an amorphous solid dispersion including a taxane or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable polymer, and a pharmaceutically acceptable surfactant, which has enhanced solubility. Also provided is a method for preparing the solid dispersion. The present subject matter also provides a tablet having good solubility, bioavailability and stability, which comprises the amorphous solid dispersion, an intragranular excipient, and an extragranular excipient.

Amorphous solid dispersion comprising taxane, tablet comprising the same, and method for preparing the same

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Seoul, South Korea

Young Su Yoon