Lg Chem, Ltd

Lg Life Sciences, Limited

Young Soo Seo

In Soo Kim

Hee Ju Kim

Gihune Jung

Jinseok Kang

Young Mee Lee

Ji Hyun Kwon

Provided is a method of manufacturing a plastic substrate with lower auto-fluorescence and better specificity. The method includes: (a) preparing a plastic substrate having an Atomic Force Microscopic (AFM) surface roughness of R&#x3c;3 nm or R&#x3c;4 nm under the condition of 50 &#x3bc;m&#xd7;50 &#x3bc;m or less; (b) treating the plastic substrate with plasma; and (c) treating the plastic substrate with a surface-modifying monomer. A plastic substrate manufactured by the method is also provided. The plastic substrate exhibits a remarkably low auto-fluorescence and thus better specificity for detection of target biomolecules, which enables the broad application of a plastic substrate, which can be easily designed to include a microfluidic structure relative to a glass substrate but has been limitedly used due to high auto-fluorescence, to microarrays, biochips, or well plates. Furthermore, the method of manufacturing the plastic substrate enables an enhancement in the surface specificity of the plastic substrate and easy adjustment of the surface characteristics of the plastic substrate.

Method of manufacturing plastic substrate using plasma process and plastic substrate manufactured using the method

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Daejeon, South Korea

Young Soo Seo