Board of Trustees of the University of Arkansas

The Texas A&m University System

University of Michigan

Columbia University

University of Kentucky Research Foundation

University of Guelph

Young Min Kwon

Billy M Hargis

Sherryll Layton

Luc Berghman

Walter G Bottje

Mandy Cox

Kimberly Cole

John R Barta

Guillermo Tellez

Donald W Landry

Chang-Guo Zhan

Shi-Xian Deng

Victor C Yang

Roger K Sunahara

James H Woods

Neil R Pumford

John J Tesmer

Diwahar L Narasimhan

Joanne MacDonald

Tien-Yi Lee

Daquan Gao

Mei-Chuan Holden Ko

Saeed El-Ashram

Said El-Ashram

Hae Kyung Kwon

Joanne Macdonald

Victor Yang

Walter Bottje

Vaccine vectors and methods for enhancing resistance toinfection or for enhancing the immune response toare provided herein. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from SEQ ID NO:-or a fragment thereof. The vector may also include an immunostimulatory polypeptide. The methods include administering the vaccine vectors to a subject.

Vaccine and methods to reduce campylobacter infection

Vaccines comprising TRAP polypeptides andvectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.

Compositions and methods of enhancing immune responses to

Compositions and methods of enhancing immune responses to Eimeria

Provided herein are13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.

Compositions and methods of enhancing immune responses

Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Anti-cocaine compositions and treatment

Vaccines comprising fliC and CD 154 polypeptides andvaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.

Compositions and methods of enhancing immune responses to flagellated bacterium

Vaccine vectors and methods for enhancing resistance toinfection or for enhancing the immune response toare provided herein. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from SEQ ID NO 7-9 or a fragment thereof. The vector may also include an immunostimulatory polypeptide. The methods include administering the vaccine vectors to a subject.

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Provided herein are13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.

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West Fork, AR, United States of America

Young Min Kwon