Arena Pharmaceuticals, Inc.

Young Mi Khulman

Michael J Martinelli

Daniel J Buzard

Antonio Garrido Montalban

John A DeMattei

Tawfik Gharbaoui

Ashwin M Krishnan

Dipanjan Sengupta

You-An Ma

Suzanne Michiko Sato

Stephen R Johannsen

The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis). 

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Plainsboro, NJ, United States of America

Young Mi Khulman