Icure Pharmaceutical Corp.

Icure Bnp Co., Ltd.

Young Kweon Choi

Jin Woo Park

Young Ro Byun

Kwan Young Chang

Jae Bum Lee

Hyun Sook Kim

Myung Jin Kim

Seong Soo Kim

Seong Su Kim

Hwan Ki Ho

Dong Hyun Hong

Hyun Suk Yu

Jae Soon Ahn

Yong Ho Oh

Song Mi Han

Hee Sook Kim

Yuseon Seo

Hyerim Na

Seohee Kang

The present invention relates to an oral pharmaceutical composition containing pemetrexed as a water-soluble anticancer drug and a method of manufacturing the same, and more particularly to an oral pharmaceutical composition, in which an ion-binding complex of pemetrexed and a bile acid derivative as an oral absorption enhancer is formed, mixed with a pharmaceutical additive, and then provided in the form of a capsule or a tablet through pressing or included in the internal water phase of a w/o/w (water-in-oil-in-water) multiple nanoemulsion, thus increasing the oral bioavailability of pemetrexed as the water-soluble anticancer drug, whereby pemetrexed, which is currently administered only in the form of an injection formulation, can be manufactured into a formulation capable of being orally administered, ultimately alleviating inconvenience and problems with use of injection formulations, improving patient compliance and contributing to a reduction in medical expenses.

Oral pharmaceutical composition containing pemetrexed and production method thereof

Provided are an oral delivery composition including oxaliplatin, a water-soluble anticancer agent, and a preparation method thereof, including forming an ionic complex with a bile acid derivative, which is an oral absorption promoter, and oxaliplatin, and incorporating it into the inner aqueous phase of a water-in-oil-in-water (w/o/w) multiple nanoemulsions, thereby obtaining the oral delivery composition with improved oral bioavailability of oxaliplatin, a water-soluble anticancer agent, avoiding the inconvenience and problems of injection, improving patient compliance, and reducing medical costs.

Oral drug delivery composition containing oxaliplatin and method for preparing same

The present invention relates to a UV-curable hydrogel resin for transdermal administration, a hydrogel prepared using the UV-curable hydrogel resin, and a cataplasm prepared using the UV-curable hydrogel resin. More particularly, the present invention relates to a hydrogel resin with an optimal composition and composition ratio which allows increase in a water content of a hydrogel applied as a drug layer of a cataplasm, skin irritation mitigation, and crosslinking degree adjustment for adhesion control and is capable of controlling drug releasing property and transdermal absorbability, a hydrogel prepared by UV-hardening the hydrogel resin, and a cataplasm including the hydrogel.

Transdermal UV-curable hydrogel resin, hydrogel curing the same and cataplasm containing the same

The present invention relates to a transdermal composition for dementia treatment containing donepezil as an active ingredient. The transdermal composition according to the present invention contains highly concentrated donepezil in a hydrophobic matrix, can continuously release the drug for a long time by having excellent long-term adhesion to the skin, and further exhibits consistently effective therapeutic effects over a long period of time by having a significantly improved skin penetration rate in comparison with conventional donepezil patches.

Transdermal composition containing donepezil as active ingredient

The patch for tooth whitening of the present invention includes a tooth-adhering layer () containing erodible polymer complexes formed by hydrogen bonding of a polymer with a carboxyl group (&#x2014;COOH) and a polymer with a carbonyl group (&#x2014;C&#x2550;O) or ether group (&#x2014;O&#x2014;) and a tooth whitening agent; and an erosion rate-controlling layer () containing a mixture of a hydrophilic polymer and a film-forming polymer, wherein the patch is in a film form and is characterized by being eroded until extinguished after releasing the tooth whitening agent. When applied to the teeth, the patch releases a peroxide tooth-whitening agent while being hydrated by water in the mouth during a prescribed period, and thereafter, eroded until extinguished, thereby not requiring an additional detaching work from the teeth. Therefore, the patch is convenient in use and greatly reduces an obstruction sensation. Moreover, the patch has an excellent whitening effect.

Patch for tooth whitening

Growing community of inventors

Seoul, South Korea

Young Kweon Choi