Ensoltek Co., Ltd.

Ensol Biosciences Inc.

Young Joon Kwon

Hae Jin Kim

Eun Joung Moon

Je Wook Lee

Yang Seon Kim

The present invention provides a peptide represented by formula (I) of X-Leu-X-Leu-Xwherein Xrepresents Glu or Asp, Xrepresents His, Lys or Arg, Xrepresents Asp or Glu, with Glu, Asp, Leu, His, Lys and Arg being respectively glutamic acid, aspartic acid, leucine, histidine, lysine and arginine; or a pharmaceutically acceptable salt thereof; a composition for the treatment or prevention of at least one selected from cartilage damage and arthritis, containing the same peptide or a pharmaceutically acceptable salt thereof as an active ingredient; and a composition containing the same peptide or a pharmaceutically acceptable salt thereof and TGF&#x3b2;1. The above-mentioned peptide or a pharmaceutically acceptable salt thereof is effective for the treatment and/or prevention of cartilage damage and/or arthritis and is capable of exhibiting effects of the regeneration of cartilage tissue, the inhibition of the expression of cartilage tissue matrix degrading enzyme and/or the inhibition of cartilage tissue ossification.

Peptide and use thereof

The present invention provides a peptide comprising an amino acid sequence of SEQ ID NO: 1 and a pharmaceutically acceptable salt thereof effective for treating degenerative disc diseases, treating body organ fibrosis, treating cancer and/or treating glomerulosclerosis, and effective for the inhibition of TGF-beta 1 signaling.

Growing community of inventors

Daejeon, South Korea

Young Joon Kwon