Caregen Co., Ltd.

Young Ji Chung

Eun Mi Kim

Young Deug Kim

Kyoung Mi Cho

Sang Su Song

Jun Young Choi

Eung Ji Lee

Eung-ji Lee

Tae-Hoon Lee

A Reum Han

Su Mi Kim

Jeong Jin Choi

Il Hwa Hong

Young-Min Lee

Sang Min Han

Tae Hoon Lee

A peptide according to the present invention can perform a function identical or similar to the function of natural CTLA-4 and has an excellent degree of skin penetration due to a small size. The peptide according to the present invention effectively binds to antigen presenting cell surface proteins (CD80 and CD86) to inhibit activity of T cells and thus is capable of inhibiting the expression of inflammatory cytokines (for example, IL-2 and IFN-&#x3b3;). As a result, a composition comprising the peptide according to the present invention exhibits excellent effects in terms of preventing, treating, or improving Th1-mediated immune diseases. Therefore, the superior activity and stability of the peptide according to the present invention can be useful when applied to medicine, quasi-drugs, and cosmetics.

Peptide for inducing mast cell-specific apoptosis and use thereof

A peptide inhibiting a matrix metalloproteinase activity, thereby improving the condition of skin and a composition containing the peptide is described, where the peptide comprises an amino acid sequence represented by the formula: X-X-Pro-Cys-X-X-X-Ser-Xand has excellent bioactivities of inhibiting the activity of hyaluronic acid degrading enzymes, adipogenesis in fat cells, angiogenesis, and the like, thereby being useful for the treatment of various disease such as obesity, cancer, and inflammation.

Peptide inhibiting matrix metalloproteanases activity and use thereof

Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics.

Noggin-derived peptide and use thereof

The present invention relates to a transforming growth factor-beta (TGF-&#x3b2;)-mimicking peptide containing a particular amino acid sequence and a composition for preventing or treating TGF-&#x3b2;-effective disorders or conditions using the same. The peptide of the present invention may be much higher stability than natural-occurring TGF-&#x3b2; and improve drawbacks caused by high molecular weight of natural-occurring TGF-&#x3b2;. The peptide of this invention can be advantageously applied to treatment or improvement of TGF-&#x3b2;-effective disorders or conditions and have excellent efficacies on skin whitening and wrinkle improvement.

Peptide having activity of transforming growth factor and production method therefor

The present invention relates to a WNT10-derived peptide, a composition for improving hair loss and skin conditions using the same, and a composition for treating a WNT10 signal transduction pathway-related disorder and DKK-1 protein-induced disorder the same. WNT10-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT10, and has much higher stability and skin penetration potency than natural-occurring WNT10. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT10 signal transduction pathway-related disorder and a DKK-1 protein-induced disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics.

WNT10-derived peptide and use thereof

Growing community of inventors

Gyeonggi-do, South Korea

Young Ji Chung