University of Iowa Research Foundation

The State University of New York

Yale University

Kestrel Corporation

Young H Kwon

Michael D Abramoff

Peter Soliz

Randy H Kardon

Markus Kuehn

Daniel Tso

Sandeep Saluja

James Bertram

Erin Lavik

John Huang

Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing one or more diseases or disorders of the eye, and methods of making and using thereof, are described. In a preferred embodiment, the microparticle compositions contain one or more active agents useful for managing elevated intraocular pressure (IOP) in the eye. Relatively hydrophilic, and preferably carboxylated, polymeric materials such as PLGA are used for a drug such as timolol maleate, which is relatively water soluble, to increase drug loading. Higher molecular weight polymers, as well as the ratio of LA (which has a longer degradation time, up to one to two years) to GA (which has a short degradation time, as short as a few days to a week), are used to provide release over a longer period of time.

Sustained intraocular delivery of drugs from biodegradable polymeric microparticles

A method of classifying an optic nerve cup and rim of an eye from a retinal image comprising receiving a retinal image, determining a feature vector for a candidate pixel in the retinal image, and classifying the candidate pixel as a cup pixel or a rim pixel based on the feature vector using a trained classifier. The retinal image can be a stereo pair, the retinal image can be color or monochrome. The method disclosed can further comprise identifying an optic nerve, identifying an optic nerve cup and optic nerve rim, and determining a cup-to-disc ratio.

Methods and systems for optic nerve head segmentation

An Optical Imaging Device of Retinal Function has been developed to detect changes in reflectance of near infrared light from the retina of human subjects in response to visual activation of the retina by a pattern stimulus. The measured changes in reflectance correspond in time to the onset and offset of the visual stimulus in the portion of the retina being stimulated. Any changes in reflectance can be measured by interrogating the retina with a light source. The light source may be presented to the retina via the cornea and pupil or through other tissues in and around the eye. Different wavelengths of interrogating light may be used to interrogate various layers of the retina. Additionally, various novel patterns and methods of stimulation have been developed for use with the imaging device and methods.

Device and method for optical imaging of retinal function

Growing community of inventors

Iowa City, IA, United States of America

Young H Kwon