Korea Atomic Energy Research Institute

Young Don Hong

Sang Hyun Park

Byung Chul Shin

Kyung Bae Park

Sun Ju Choi

Sang Mu Choi

Beom Su Jang

Hui Jeong Gwon

Woong Woo Park

Kwang Hee Han

A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compound. The method can directly label disulfide compounds with technetium or rhenium, can skip the synthetic step of thiol-protected S-precursor, and is useful for high value-added radiopharmaceuticals.

Method for labelling technetium or rhenium using borohydride exchange resin

The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER). The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2&#x2dc;14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.

Method for the preparation of technetium or rhenium complex for radiopharmaceuticals

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Daejeon, South Korea

Young Don Hong