Industry-academic Cooperation Foundation Gyeongsang National University

Korea Research Institute of Bioscience and Biotechnology

Seoul National University

Gwangju Institute of Science and Technology

Syntekabio, Inc.

Snu Rdb Foundation

Industry-academic Cooperation Foundation

Young Bae Ryu

Ki Hun Park

Hyung Won Ryu

Woo Song Lee

Jung Weon Lee

Mun Chual Rho

Jae Cheol Jeong

Yu Jeong Jeong

Suk Weon Kim

Cha Young Kim

Sin-Ae Lee

Young Min Kim

Jiyoung Lee

Ji Young Park

Dong Myung Kim

Su Jin Park

Bong Hwan Park

In Chul Lee

Seung Woong Lee

Suhyun Park

Sung-Chul Park

Soo Hyun Eom

Kyoung Oh Cho

Mi Hye Park

Hyung Jun Kwon

Jung Keun Cho

Ji Hak Jeong

Jong Sun Jung

Jin Hyo Kim

Jong Sun Chang

Jong Hui Hong

Woo Duck Seo

Sang Wan Gal

Hyun Mee Oh

The present invention relates to a method for producing a dimeric stilbene using a plant callus culture solution. More specifically, the present invention relates to a method for producing a dimeric stilbene using a plant callus culture solution and a composition for dimeric stilbene production, which contains a plant callus culture solution as an active ingredient.

Dimeric stilbene production method using callus culture medium of plant

Disclosed is a pharmaceutical composition for preventing or treating severe acute respiratory syndrome coronavirus 2 infection disease, the composition comprising a compound represented by a Chemical Formula 1, or a pharmaceutically acceptable salt thereof, as an active ingredient.

Composition for preventing or treating SARS coronavirus 2 infection disease

The present invention relates to a method for mass-production of viniferin using stevioside from cell culture of grape tree tissue. Viniferin is known to be effective for protection of liver, anticancer, antioxidant, and skin whitening, have an effect of inhibiting oxidation of low-density lipoprotein and high-density lipoprotein and inhibiting the proliferation and migration of vascular smooth muscle cells. Therefore, the present invention is very useful for the mass production of viniferin among the useful substances (stilbene compounds) from a callus derived from the anther tissue of the grape plant, which is very important for the related industries.

Method for mass-producing viniferin using stevioside from cell culture of grapevine tissue

The present invention relates to a composition for suppressing neuraminidase activity comprising a geranylated flavonoid derived fromas an active ingredient. Theextract and the geranylated flavonoid isolated therefrom exhibit an effect in significantly suppressing neuraminidase, which is an enzyme that plays an important role in the occurrence of pathogenic viral and bacterial infections and of the inflammation that accompanies such infection, and thus theextract or the geranylated flavonoid isolated therefrom can advantageously be used as an active ingredient in a composition for inhibiting neuraminidase activity.

Composition for suppressing neuraminidase activity comprising geranylated flavonoid derived fromas active ingredient

The present invention relates to a composition for enhancing immunity through inducing the expression of interferon-&#x3b2; comprising a compound represented by Formulas 1 to 8, orextract comprising the same and fractions thereof as an active ingredient, a feed additive, feed composition, pharmaceutical composition, food composition, and over-the-counter (OTC) drug composition comprising the composition, and a method for enhancing immunity through administrating the composition. A composition for inducing the expression of interferon-&#x3b2;, comprising a compound represented by Formulas 1 to 8 of the present invention,extract comprising the same, or fractions thereof as active ingredient can prevent, alleviate, or treat the diseases that can be prevented or treated by increasing the expression of interferon.

Composition for enhancing immunity containing compounds represented by chemical formulas 1-8 or sophora flavescens extract as active ingredient

The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.

Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds

Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.

Chalcone derivatives, pharmaceutically acceptable salt, method for preparation and uses thereof

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Daejeon, South Korea

Young Bae Ryu