Catholic University Industry Academic Cooperation Foundation

The Catholic University of Korea Industry-academic Cooperation Foundation

Korea Greencross Corporation

Young Ae Joe

Hyun Kyung Kim

Jong Hyuk Lee

Soo-Ik Chang

Young Jo Kim

Soo-Il Jung

Hyosil Lee

Byung Cheul Ahn

Seung Ho So

Hyun-Kyung Kim

Yong-Kil Hong

Weon Kyoo You

The present invention is related to a medium additive composition comprising peroxidasin for serum-free cell culture, and a method of performing serum-free culture of cells by using the same.

Serum-free medium additive composition containing peroxidasin, and use thereof

Provided are peptides having anti-angiogenic activity and a use thereof, and more particularly, to peptides for inhibiting angiogenesis, the peptides including amino acid sequence with potent anti-angiogenic activity, a composition for inhibiting angiogenesis, the composition including the peptides, a medicine for inhibiting angiogenesis, the medicine including the composition, and a method for inhibiting angiogenesis using the peptides. The peptides for inhibiting angiogenesis, the peptides including the amino acid sequence of the invention provides not only potent inhibitory activity on proliferation, migration and tube formation of vascular endothelial cells, but also potent in vivo anti-angiogenic activity and inhibitory activity on proliferation and migration of cancer cells. Therefore, the peptide for inhibiting angiogenesis can be efficaciously used as a treatment for various diseases including cancer with abnormal regulation of angiogenesis.

Peptide having a vascularization-suppressing activity and a use therefor

The invention relates to a composition for angiogenesis inhibition comprising a peroxidasin inhibitor as an effective ingredient, and more particularly, to a method of screening angiogenesis inhibitor, which includes steps of treating a test agent, and analyzing peroxidasin gene expression or protein activity, and comparing peroxidasin gene expression or protein activity between a case treated with the test agent and a case not treated with the test agent. Accordingly, since the inhibitor of the peroxidasin expression or protein activity according to the present invention can effectively inhibit migration, proliferation and tube formation of endothelial cells, the inhibitor can be effectively used for preventing or treating a variety of diseases or conditions of the diseases derived from abnormal regulation of angiogenesis.

Composition for inhibiting angiogenesis containing a peroxidasin inhibitor as an active ingredient

The present invention relates to process of purifying the angiogensis inhibitor proteins expressed in and to the use of recombinant kringle 1-3 (; greenstatin) purified by the above process as a angiogenesis inhibitor and an anticancer agent. Particularly, according to the process of purifying the protein, the angiogenesis inhibitor proteins overexpressed are solubilized, refolded, and purified as a pure and active form. The greenstatin purified by the process specifically suppresses endothelial cell proliferation, anaiogenesis, and the growth of lung cancer, skin cancer, and brain tumor. Therefore, the process of this invention is applicable to the mass-production of angiogenesis inhibitor proteins such as greenstatin which is useful for the treatment of glaucoma, retinopathy, and cancers.

Process of purifying angiogenesis inhibitors

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Seoul, South Korea

Young Ae Joe