Korea Institute of Science and Technology

Cnpharm Co. Ltd.

Board of Trustees, Ewha Womans University

Ewha University-Industry Collaboration Foundation

Il-yang Pharm. Co., Ltd

Youn Soo Sohn

Yong Joo Jun

Prakash Gouda Avaji

Sang Beom Lee

Soo-Chang Song

Kwan Mook Kim

Chong Ock Lee

Joo Hyung Kim

Young A Lee

Young-A Lee

Ji Yeon Seong

Ok S Jung

Hyoung Gee Baek

Rita Song

Ok-Sang Jung

Yang Ha Cho

Hyounggee Baek

Sung Sil Lee

Joo Ik Kim

Sung Mo Choi

Yeong-Sang Kim

Bae Hoon Lee

The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.

Cationic polyphosphazene compound, polyphosphazenes-drug conjugate compound and method for preparing same

A cyclotriphosphazene represented by Formula 1 prepared by introducing a dendritic tetrapeptide and a hydrophilic polyethylene glycol into a cyclotriphosphazene ring, a method of preparing the same, and a drug carrier including the cyclotriphosphazene of Formula 1. The compound according to the present invention may form a strong molecular hydrogel in a very low concentration of 2 w/w % or less. Furthermore, the hydrogel prepared using the compound of Formula 1 exhibits biodegradability, thermosensitivity at around body temperature, biocompatibility with protein drugs, and an easy way to prepare along with a sustained release property without any burst effect in the early stage of release. Therefore, the present cyclotriphosphazene molecular hydrogel may be efficiently used as a drug carrier for a sustained release of a drug, particularly, a protein drug.

Dendritic oligopeptide-grafteded cyclotriphosphazene, a process for the preparation thereof and a drug delivery system containing the same

The present invention relates to a thermosensitive and biocompatible poly(organophosphazenes) represented by Formula 1, and a preparation method thereof: 

Thermosensitive and biocompatible amphiphilic poly(organophosphazenes) and preparation method thereof

Disclosed are a new class of a polyphosphazene-platinum(II) conjugate antitumor agent having high tumor tissue selectivity due to its enhanced permeability and retention effect to tumor tissues, and a preparation method thereof:wherein x represents the number of the ethylene oxide repeating unit and is 7, 12 or 16; y is 0, 1 or 2; z represents molar content of polyethylene glycol in the range of 0.5-1.5; n represents degree of polymerization of polyphosphazene in the range of 30-100; and A-A represents a diamine.

Tumor selective and biodegradable polyphosphazene-platinum(II) conjugate antitumor agent, and preparation method thereof

Disclosed are a platinum (II) complex of N-substituted amino dicarboxylate showing antitumor activity represented by the following formula (1) and a preparation method thereof:wherein n is 1 or 2; A&#x2014;A is a diamine selected from the group consisting of trans-(&#xb1;)-1,2-diaminocyclohexane, ethylenediamine and 2,2-dimethyl-1,3-propanediamine; and Ris hydrogen and Ris RCO or RSO, wherein R is an alkyl selected from the group consisting of methyl, ethyl, n-propyl, n-butyl and t-butyl or an aryl selected from the group consisting of phenyl and substituted phenyl group, or RRis phthaloyl.

Platinum(II) complexes of N-substituted amino dicarboxylates and the preparation method thereof

The present invention relates to novel cyclotriphosphazene derivatives represented by Formula (1) and a preparation method thereof wherein HNA is an amino acid group selected from glycine group(&mdash;NHCH COO ), aminomalonic acid group(&mdash;NHCH(COO ) ), aspartic acid group (&mdash;NHCH(CH COO )COO ) and glutamic acid group (&mdash;NHCH(CH CH COO )COO ), m is a repeating unit of poly(alkoxyethyleneglycol) selected from 2, 7, 12 and 16, and n is an integer representing number of alkyl carbons and selected from 0, 1, and 3.

Thermosensitive cyclotriphosphazene derivatives and a preparation method thereof

The present invention provides a novel thermosensitive cyclotriphosphazene-platinum complex conjugates represented by Formula 1,

Thermosensitive cyclotriphosphazene-platinum complex conjugate, its preparation method and anticancer agent containing the same

The present invention relates to novel biodegradable polyphosphazenes represented by Formula 1 and a preparation method thereof. Polyphosphazenes of the present invention not only have thermosensitivity and biodegradability simultaneously, but also their phase transition temperature and degradation rate can be controlled.

Biodegradable and thermosensitive polyphosphazenes and their preparation method

The present invention relates to a platinum complex conjugated to a cyclotriphosphazene represented by Formula 1 and a preparation method thereof. The platinum complex according to the present invention can be used as an anticancer agent.

Platinum complex conjugated to cyclotriphosphazene, its preparation, and anticancer agent comprising the same

Platinum (IV) complexes for oral administration represented by the structural formula ##STR1## where A--A is a symmetrical diamine that can chelate to platinum and is selected from the group consisting of ethylene diamine, t(.+-.)-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-propanediamine, cyclohexane-1,1-dimethaneamine and tetrahydro-4H-pyran-4,4-dimethaneamine; and R is propionyl, butyryl or valeryl. These complexes are useful in the treatment of cancer.

Anticancer (IV) complexes for oral administration and a method of making

A novel polymeric platinum complex represented by the following formula (I): ##STR1## wherein, S, A, x, m and n are defined as above, a process for preparation thereof, and the use thereof as an anticancer agent.

Growing community of inventors

Seoul, South Korea

Youn Soo Sohn