The University of Texas System

Louisiana State University and Agricultural & Mechanical College

Henry Ford Health System

Youjun Yang

Eric V Anslyn

Robert Michael Strongin

Jerry Yee

Isiah Manuel Warner

Stanley Frinak

Jorge O Escobedo Cordova

Balazs Szamosfalvi

Mark Lowry

Sayo O Fakayode

Xiangyang Xu

Michelle M Adams

Nitric oxide probes including a compound represented by Formula, I, II, III, IV, V, VI or a combination thereof are provided. Methods of using these nitric oxide probes to detect nitric oxide are also provided.

Fluorescent nitric oxide probes and associated methods

Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in 'multiplexing' techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges. 

Fluorescent xanthenes and white light fluorophores

Growing community of inventors

Austin, TX, United States of America

Youjun Yang