National Institute of Advanced Industrial Science and Technology

Chugai Seiyaku Kabushiki Kaisha

Other

Youji Mitsui

Renu Wadhwa

Sunil Kaul

Takashi Sugihara

A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis and to encode a protein, Tesmin, which may regulate the differentiation of spermatogeneous cells into primary spermatocytes. Tesmin proteins are described herein, as are antibodies that bind to such proteins.

Antibodies to a testis-specific differentiation-regulatory factor

A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis.

Growing community of inventors

Ibaraki, Japan

Youji Mitsui