Kyowa Hakko Kogyo Co., Ltd.

Youichi Uosaki

Hirofumi Nakano

Eiji Kobayashi

Keiko Ochiai

Tamio Mizukami

Hiroshi Sano

Yutaka Kanda

Yoshinori Yamashita

Yutaka Saitoh

Makoto Morimoto

Hiromitsu Saito

Satoru Nagamura

Noboru Fujii

Akira Asai

Shiro Akinaga

Katsuhiko Ando

Tadashi Ashizawa

Eiji Tsukuda

Kazuo Aisaka

Yuzuru Matsuda

Yasushi Sakai

Shigeru Chiba

Takeo Tanaka

Tsutomu Agatsuma

Shigeo Katsumata

Akira Mihara

Hidemasa Kondo

Shingo Kakita

Katsunori Kita

Fumito Koizumi

Tetsuo Yoshida

Yukari Tsuji

Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.

Interleukin-1 production inhibiting compound

Process for producing disaccharides and novel disaccharides

Disclosed is Compound GEX1 of formula (I), having excellent antitumor activity: ##STR1## wherein R.sup.1 represents hydroxy or ##STR2## R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen or hydroxy; R.sup.5 represents hydroxyl or lower alkoxy; provided that when R.sup.1 is hydroxy and R.sup.5 is methoxy, then at least one of R.sup.2, R.sup.3 and R.sup.4 is the group except for hydrogen, and pharmaceutically acceptable salts thereof.

Compound GEX1

UCH15 compounds

Substance DC114-A1

A compound represented by formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is provided, which has an excellent antitumor activity.

Compound UCE6

DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO.sub.2 R.sup.1 (in which R.sup.1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4 carbon atoms, allyl, or benzyl); and ##STR2## have an excellent anti-tumor activity and are useful as anti-tumor agents.

Pyrroloindole derivatives

Pyrroloindole derivatives related to DC-88A compound

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Machida, Japan

Youichi Uosaki