Fujisawa Pharmaceutical Company, Ltd.

Youichi Shiokawa

Atsushi Akahane

Takafumi Mitsunaga

Hirohito Katayama

Ikuo Ueda

Kazuo Okumura

Tsutomu Toyonaka Teraji

Kazuhiko Take

Yoshinari Sato

Takashi Manabe

Kazunori Tsubaki

Koichi Takimoto

Hiromichi Itani

Kohei Takenaka

Teruo Kyoto Oku

Takashi Kamiya

Takeshi Kato

Masanobu Nagano

Yousuke Katsura

Masashi Hashimoto

Takao Takaya

Hisashi Takasugi

Keiji Hemmi

Osamu Nakaguti

Masayuki Kato

Nobukiyo Konishi

Tadaaki Komori

Yoshihisa Saito

Kunihiko Tanaka

Kiyoshi Taniguchi

Atshushi Akahane

This invention relates to novel (+)-5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. More particularly, it relates to novel (+)-5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, which has pharmacological activities such as hypotensive and vasodilating activities, to a pharmaceutical composition comprising the same and to a method for treating hypertension, cardiovascular diseases, and the like. Accordingly, one object of this invention is to provide novel (+)-5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, which is of use for treating hyperxtension, cardiovascular diseases, and the like.

(+)-5-isopropyl 3-methyl 2-cyano-6 methyl-4-(3-nitrophenyl)-1,

This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by the general formula [I]: ##STR1## wherein R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with halogen, etc.,

Ethanolamine derivatives having sympathomimetic and anti-pollakiuria

The present method for the treatment of pancreatitis, which comprises administering an effective amount of a pyrazolopyridine compound of the following formula: ##STR1## wherein R.sup.1 is lower alkyl, (substituted) aryl, or a heterocyclic group,

New use of the adenosine antagonist

The disclosure concerns pyrazolopyridine compounds of the formula

Pharmaceutically useful pyrazolopyridines

The compound (-)-N-t-butyl-4,4-diphenyl-2-cyclopentenylamine, or its hydrochloride salt has anticholinergic activity, and thus has a variety of pharmaceutical utilities.

Substituted-amine compound and a process for the preparation thereof

This invention relates to pyrazolopyridine compounds for the treatment of melancholia, heart failure, hypertension, renal insufficiency, renal toxicity, nephrosis, nephritis, edema, obesity, bronchial asthma, gout, hyperuricemia, sudden infant death syndrome, immunosuppression, diabetes, myocardial infarction, thrombosis, obstruction, arteriosclerosis obliterans, thrombophlebitis, cerebral infarction, transient ischemic attack or angina pectoris, said compounds being of the formula ##STR1## wherein the radicals are defined in the claims.

Pyrazolopyridine compounds which have useful pharmaceutical utility

There are disclosed 3 [2(substituted alkyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-aryl pyrazolo [1,5-a]-pyridines useful for treating maladies requiring an adenosine antagonist, and preparative processes.

Pyrazolopyridine compounds

Compounds of the formula ##STR1## wherein R.sup.1 is aryl which may have one or more suitable substituent(s)

Substituted-acetamide compound and a process for the preparation thereof

The disclosure deals with pyrazolopyridine compounds of the formula: ##STR1## wherein the variables are defined in the specification. The compounds are useful as a diuretic, anti-hypertensive agent, etc.

The invention relates to a method for the prevention and/or treatment of renal toxicity, nephrosis or nephritis, which comprises administering a pyrazolopyridine compound of the formula: ##STR1## wherein R.sup.1 is aryl, and

Method of treatment using pyrazolopyridine compound

Benzopyrene derivatives effective for the treatment of hypertension have been prepared.

Benzopyran derivatives and processes for preparation thereof

The invention relates to a method for the treatment of renal toxicity, nephrosis or nephritis which comprises administering an effective amount of the pyrazolopyridine compounds of the invention.

Method of treating kidney disease using pyrazolopyridine compound

The invention relates to a method for the treatment of ailments which comprises administering an effective amount of the pyrazolopyridine compounds of the invention.

Pharmaceutical method of treatment using pyrazolopyridine compound

The invention relates to novel pyrazolopyridine compounds useful as a diuretic, antihypertensive agaent, for renal insufficiency, for thrombosis, and as a cardiotonic agent.

Pharmacologically active pyrazolopyridine compounds

Compounds of the formula ##STR1## wherein R.sup.1 is aryl which may have one or more suitable substituent(s),

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Ibaraki, Japan

Youichi Shiokawa