Kuraray Co., Ltd.

Eisai R&d Management Co., Ltd.

Youichi Satake

Kenichi Koyakumaru

Yoshimi Fukunaga

The present invention provides a method of industrially and advantageously producing a 5-(2'-pyridyl)-2-pyridone derivative. The present invention relates to a production method of a 5-(2&#x2032;-pyridyl)-2-pyridone derivative represented by the formula (VI), which includes reacting a pyridine derivative of the formula (I) with a brominating agent to give a 5-bromopyridine derivative of the formula (II), reacting the obtained 5-bromopyridine derivative with a metallizing agent to give an organometallic compound of the formula (III), reacting the obtained organometallic compound with a 2-sulfonylpyridine derivative of the formula (IV) to give a 6-alkoxy-3,2&#x2032;-bipyridine derivative of the formula (V) and hydrolyzing the obtained 6-alkoxy-3,2&#x2032;-bipyridine derivative: wherein each symbol is as defined in the Description.

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Kurashiki, Japan

Youichi Satake