Daiichi Pharmaceutical Co., Ltd.

Max Co., Ltd.

Daiichi Sankyo Company, Limited

Daiichi Seiyaku Co., Ltd.

Youichi Kimura

Makoto Takemura

Isao Hayakawa

Hisashi Takahashi

Hitoshi Ohki

Kenichi Kimura

Katsuhiro Kawakami

Yohhei Ishida

Rie Miyauchi

Shohgo Atarashi

Masazumi Imamura

Kazuyuki Sugita

Satoru Miyauchi

Norikazu Matsuhashi

Michiaki Adachi

Terufumi Hamano

Noboru Ishikawa

Takashi Ishiyama

Yuichi Ochiai

Naoaki Kanaya

Hiroshi Hanagasaki

Yusuke Yukimoto

Haruko Kawato

Keiji Uchiyama

Tazuo Uemura

Norimasa Mikata

Satoshi Osuka

N-(1,2-cis-2-halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by the following formula (I) the terms of which are defined in the specification and the salts thereof are disclosed:These compounds have patent antibacterial activities against a wide variety of infectious bacteria and are useful as antibacterial agents by oral or parenteral administration.

Optically active pyridonecarboxylic acid derivatives

The present invention is directed to a strong platelet aggregation-inhibiting agent which does not inhibit COX-1 or COX-2. Further, the present invention provides compounds represented by formula (I), salts of the compounds, and solvates or hydrates of the compounds or the salts. Also provided are medicaments containing any of the compounds, salts, or solvates and preventive and/or therapeutic agents for ischemic diseases, containing any of the compounds, salts, or the solvates or hydrates. 

Pyrazole derivatives having a pyridazine and pyridine functionality

The present invention relates to an antimicrobial compound having high safety as well as potent antimicrobial activity on a broad range of microorganisms represented by the following formula:

Cis-substituted aminocyclopropane derivative

The present invention provides an antibacterial compound useful as medicines, animal drugs, fisheries drugs or antibacterial preservatives and to an antibacterial agent or preparation which contains the same, more particularly a compound which possesses high safety and excellent activity against a broad range of bacterial species including quinolone-resistant strains. A quinolone derivative of the following formula (I) which has a group derived from the heterocyclic spiro-compound at the 7-positioned R and the halogenocyclopropyl group at the N -position, prefereably a compound of pure isomer, and an antibacterial agent containing the derivative compound.

Heterocyclic spiro-derivative

Cis-substituted aminocyclopropane derivatives

A quinolone derivative represented by formula (I):

Cycloalkylaminomethylpyrrolidine derivatives

An antimicrobial drug having excellent antimicrobial activity and high safety is disclosed, which comprises as an active ingredient, a quinolone derivative having a substituted aminocycloalkylpyrrolidine as a substituent and which is further substituted with various substituents, represented by formula (I), its salts and hydrates thereof:

Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives

An antimicrobial drug having excellent antimicrobial activity and high safety is disclosed, which comprises as an active ingredient, a quinolone-derivative having a substituted aminocycloalkylpyrrolidine as a substituent and which is further substituted with various substituents, represented by formula (I), its salts and hydrates thereof: ##STR1## wherein Q is represented by formula (II) or (IV). ##STR2## Also disclosed is a quinolone derivative where R.sup.4 and the substituent on the pyrrolidine ring of the following formula: ##STR3## are located at the cis-configuration; and Q is represented by the formula: ##STR4##

Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted

N.sub.1 -(1,2-cis-2-halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by the following formula (I) the terms of which are defined in the specification and the salts thereof are disclosed: ##STR1## These compounds have patent antibacterial activities against a wide variety of infectious bacteria and are useful as antibacterial agents by oral or parenteral administration.

Pyridonecarboxylic acid derivatives substituted by a bicyclic amino

A nail guide device of a box nailing machine in which a nail connected with another nail by a tying member is driven by a drive rod, the nail guide device includes: a nail magazine for accommodating the nails connected with each other; a nose for guiding the driver rod; a nail guide plate for connecting the nail magazine with the nose, including, a lower end portion extending downward to a position lower than a tip of the nail, and a guide groove provided in an upper portion of one face of the nail guide plate and extending over the entire length of the guide plate; and a nail cover rotatably provided opposite to the face on which the guide groove is formed, the nail cover and the guide plate forming a nail path, wherein the guide groove is engaged with a side portion of the head of the nail to guide the nail from the nail magazine to the nose; and a flange protruding to the nail path formed in the lower end portion of the nail guide plate so as to shield the tip of the nail.

Nail guide device of a box nailing machine

A box nailing machine includes a piston within a cylinder to drive a nail. A main selector valve introduces compressed air into the cylinder and discharges the compressed air from the cylinder. A start operation valve operates the main selector valve. A trigger device for the box nailing machine comprises: a trigger switch operated by a trigger lever; a contact switch operated by the contact arm; an electromagnetic valve serving as the start operation valve; a logical circuit for applying a drive current to the electromagnetic valve when both the trigger switch and the contact switch are turned on; and a controller which includes a timer with a predetermined time limit. The timer is started in accordance with a trigger signal of the trigger switch and prohibits the drive current from the electromagnetic valve when the timer counts the predetermined time period. The timer is reset upon release of the trigger.

Trigger device for box nailing machine and box nailing machine having

N.sub.1 -(1,2-cis-2-halogenocydopropyl)-substituted pyridonecarboxylic acid derivatives represented by formula (I) and the salts thereof are disclosed. These compounds have patent antibacterial activities against a wide variety of infectious bacteria, and are useful as antibacterial agents by oral or parenteral administration.

Growing community of inventors

Tokyo, Japan

Youichi Kimura