University of South Florida

Wisconsin Alumni Research Foundation

Youhong Niu

Jianfeng Cai

Haifan Wu

Shruti Padhee

Weibo Cai

Hao Hong

The present invention is directed to a novel class of antimicrobial agents called &#x3b3;-AApeptides. The current invention provides various categories of &#x3b3;-AApeptides, for example, linear &#x3b3;-AApeptides, cyclic &#x3b3;-AApeptides, and lipidated &#x3b3;-AApeptides. &#x3b3;-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. &#x3b3;-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed &#x3b3;-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

Gamma-AApeptides with potent and broad-spectrum antimicrobial activity

&#x3b3;-AApeptides with potent and broad-spectrum antimicrobial activity

Embodiments of the present disclosure provide for RGD mimetic &#x3b3;-AApeptide compounds, &#x3b3;-AApeptide compounds capable of binding an RGD binding site on integrin &#x3b1;&#x3b2;, linear &#x3b3;-AApeptide compounds, cyclic &#x3b3;-AApeptide compounds and multimeric RGD mimetic &#x3b3;-AApeptide compounds, methods of making each, and methods of using each, and the like. In embodiments, the RGD mimetic &#x3b3;-AApeptide compounds can be used in imaging, diagnostics, and treatment of angiogenesis related conditions.

RGD mimetic &#x3b3;-AApeptides and methods of use

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Tampa, FL, United States of America

Youhong Niu