University of Pennsylvania

Shenzhen Institutes of Advanced Technology

Youhai H Chen

James M Wilson

Ramachandran Murali

Shaowen Wang

Jing Sun

Tingting Fan

Xiaochun Wan

Qingguo Ruan

Yifan Ma

Lintao Cai

The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.

C-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis

This invention provides REL inhibitors which interfere with the DNA binding capacity of a REL protein. Additionally this invention provides methods of treating, abrogating, or preventing diseases which respond with a positive clinical score to a REL inhibitor. Methods of identifying REL inhibitor based on a REL protein three dimensional model are described.

Rel inhibitors and methods of use thereof

A method for tolerizing a mammalian subject to administration of a live virus carrying a gene for delivery to a cell of the subject is disclosed. The method entails administering to the subject a suitable amount of an inactivated virus prior to administration of the live virus. The prior administration of the inactivated virus suppresses anti-virus cytotoxic T cells, permitting longer transgene persistence once the live virus is administered, and permitting effective readministration of live virus.

Method for tolerizing a mammalian patient to administration of gene therapy virus vectors

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Philadelphia, PA, United States of America

Youhai H Chen