Zhejiang Nhu Company Ltd.

Zhejiang University

Shandong Nhu Pharmaceutical Co., Ltd.

Shandong Nhu Fine Chemical Science and Technology Company Ltd.

Yougui Zhou

Haoran Li

Ming Yu

Zhirong Chen

Lei Zhao

Yin Zhang

Yuhong Zhang

Weikang Shao

Jintao Yuan

Guangxiong Yu

Fuxiang Deng

Weiwei Su

Xiandong Zhu

Xingxing Shi

Kaifeng Ma

Yugang Wang

Wei Xue

Ming Feng

Yu Ding

Sheng Yu

Xiaoqiao Wei

Jiang Cai

Wenwu Yan

Yunhan Yang

Yu Sheng

A method for synthesizing sucrose-6-ester includes: (a) in the presence of a polar aprotic solvent, contacting an organic phosphine compound represented by formula I with sucrose and an organic tin compound; (b) removing water to obtain a reaction liquid containing a tin-sucrose adduct; and (c) contacting the reaction liquid containing the tin-sucrose adduct with an acid anhydride compound to prepare a sucrose-6-ester. In formula I, R, R, and Reach are a linear or branched alkyl having 1 to 20 carbon atoms, a cycloalkyl having 3 to 10 carbon atoms, or an aryl having 6 to 10 carbon atoms; moreover, the R, R, and Rare identical groups, partially identical groups, or different groups from each other. According to the method, the reaction conversion rate and selectivity are greatly improved; moreover, it is easy to realize industrial application.

Method for synthesizing sucrose-6-ester

The present invention discloses a method for preparing sucralose-6-acetate in a biphasic liquid-liquid system. The method comprises slowly dropwise adding an inert non-polar solvent containing a chlorinating agent to an N,N-dimethyl formamide (DMF) solution of sucrose-6-acetate; then reacting the biphasic liquid-liquid mixture at a certain temperature for 9-20 hours; cooling the system to room temperature after stopping heating, and settling the solution to form layers, an upper layer being an inert non-polar solvent layer, and a lower layer being a DMF solution layer containing the product; hydrolyzing, neutralizing, and filtering the lower layer to obtain a filtrate, and then concentrating the filtrate to obtain a concentrate; dissolving the concentrate in water, and obtaining the product by extraction using ethyl acetate and crystallization, the inert non-polar solvent being an alkane solvent containing 8-18 carbon atoms that is not mutually soluble with DMF. The method has a high product yield, and can significantly reduce the decomposition of DMF, thereby reducing costs.

Method for preparing sucralose-6-acetate in biphasic liquid-liquid system

The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use &#x3b1;, &#x3b2;-unsaturated aldehydes or &#x3b1;, &#x3b2;-unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical.

Method for preparing optically active carbonyl compound

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Shaoxing, China

Yougui Zhou