Optimer Pharmaceuticals, Inc.

Merck Sharp + Dohme Corp.

Youe-Kong Shue

Yu-Hung Chiu

Alex Romero

Yoshi Ichikawa

Chan-Kou Hwang

Jonathan James Duffield

Farah Kondori Babakhani

Tessie Mary Che

Franklin W Okumu

Yoshitaka Ichikawa

David Rabuka

Kenneth Marby

Pamela Sears

Yuan-Ting Chen

Mei-Chiao Wu

Chi-Jen Frank Du

Sulan Yao

Steve Sucheck

Chang-Hsing Liang

Jonathan Duffield

Ming-Hsi Chiou

Ming-His Chiou

Starr Louise Miller-Shangle

Pamela Suzanne Sears

Robert Brian Walsh

Yoshiaki Ichikawa

Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.

Antibacterial agents

The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of() and().

Antibiotic macrocycle compounds and methods of manufacture and use thereof

The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to(''),(''),species, for example, methicillin-resistant, orincluding Vancomycin-resistant enterococci.

Macrolide polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to(''),(''),species, for example, methicillin-resistant, orincluding Vancomycin-resistant

Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the speciessubspecieshaving the ability to produce and accumulate one or more Tiacumicin in a nutrient medium comprising a carbon source, a nitrogen source, trace elements such as inorganic salts, and an adsorbent, wherein said nitrogen source comprises fish powder, and wherein said Tiacumicin is produced in a yield greater than about 50 mg/L broth.

Tiacumicin production

The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specificallyinfections.

18-membered macrocycles and analogs thereof

Macrocyclic polymorphs, compositions comprising such polymorphs and methods of use and manufacture thereof

Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.

Growing community of inventors

Carlsbad, CA, United States of America

Youe-Kong Shue