Merck Sharp + Dohme Corp.

Cubist Pharmaceuticals, Incorporated

Biosource Pharm, Inc.

Calixa Therapeutics, Inc.

You Seok Hwang

Valdas Jurkauskas

Kristos Adrian Moshos

William V Curran

Blaise S Lippa

Giovanni Fogliato

Richard A Leese

Christopher Matthew Liu

Sudhakar Devidasrao Garad

Yanzhi Zhang

Jian-Qiao Gu

Manuel Scanu

Amy C D Bombardier

Joseph Terracciano

Nicole Miller Damour

Pradip M Pathare

Jacob P Sizemore

Lisa Duong

Sanjay Mudur

Asli Ovat

Carlos Lopez

Jason Woertink

Akash Jain

Described herein are crystalline forms of a compound of formula (III'), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.

Intermediates in the synthesis of cephalosporin compounds

Described herein are crystalline forms of a compound of formula (II&#x393;), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (II&#x393;): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.

This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for making these salt forms and compositions comprising the same. The salt forms provided herein include ceftolozane bromide, ceftolozane edisylate, ceftolozane mesylate, ceftolozane chloride, ceftolozane sulfate, ceftolozane maleate, ceftolozane phosphate, and ceftolozane ketoglutarate.

Salt forms of ceftolozane

This disclosure provides compositions containing solid forms of sodium (2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate, and methods of manufacturing and using these compositions.

Crystalline form of a &#x3b2;-lactamase inhibitor

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

Antibiotic compositions for the treatment of gram negative infections

Novel solid forms of ceftolozane are described, as well as methods for the preparation and use of these solid forms.

Solid forms of ceftolozane

Growing community of inventors

Windham, NH, United States of America

You Seok Hwang