Nanopass Technologies Ltd.

Yotam Levin

Gal Admati

Yehoshua Yeshurun

Meir Hefetz

Yoav Hamisha

Gilad Lavi

Yoel Sefi

Gil Fruchtman

Yehushua Yeshurun

An injection configuration () for connection to a male Luer connector () includes a hub () having an internal conical taper () in fluid interconnection with a hollow needle (). The internal conical taper has a convergence angle of 6% and a length L of 7.5-10.5 millimeters, and presents an entrance aperture diameter D of between 4.365 and 4.595 millimeters.

Injection configuration with modified Luer connector for reduced dead space

Round needle head

A microneedle structure has one or more microneedles () projecting from the major surface () of a substrate (). The microneedle has a penetrating tip () formed at an intersection between upright surfaces () and an inclined surface () corresponding to a (1 1 1) crystallographic plane. The microneedle has an expanding portion bounded by a continuation of the upright surfaces () and inclined surface (), and a constant cross-section portion bounded by a continuation of the upright surfaces and a slicing plane () extending from an edge () of inclined surface () towards, and perpendicular to, major surface () of the substrate. A width W of inclined surface () increases monotonically from penetrating tip () to edge ().

Silicon microneedle structure and production method

A microneedle for intradermal injection or diagnostics, constructed as a protrusion above a substrate and whose shape is defined by a pair of vertical side surfaces, configured to be symmetrical about a vertical plane of symmetry and to meet along a vertical leading edge, and by an inclined surface, intersecting the side surfaces, the microneedle also including a vertical bore, located centrally between the two side surfaces and substantially near the leading edge, wherein each of the side surfaces is divided, sequentially along the front-to-back direction, into at least two contiguous planar segments, forming pairs of corresponding segments along the respective side surfaces; each pair of corresponding segments mutually form an acute angle, the angle being between 40 and 70 degrees for the pair of segments adjacent the leading edge and less than 35 degrees for the pair of segments farthest from the leading edgeand wherein the leading edge is formed so that its profile includes an arc, joined to the side surfaces.

Microneedle structure for intradermal injection

A device for delivering a fluid into a biological tissue includes hollow microneedles () projecting from a surface () of a substrate (), and a guide element () spaced from the substrate. The guide element provides a tissue-contact surface () that defines a tissue contact plane oblique to the surface () of the substrate ().

Microneedle device with mechanical guide

A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles () inserted into the biological barrier () is generally sideways projecting from the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles () project from a relief surface () which is distinct from a primary biological-barrier contact region () of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region () is brought into contact with the biological barrier () and moved parallel to the surface of the flexible biological barrier so as to generate a boundary () between a stretched portion () and a non-stretched portion () of the barrier. Typically concurrently with this motion, the microneedles () penetrate into the flexible biological barrier such that, at the end of the motion, the microneedles extend into the flexible biological barrier from the boundary region () in a direction towards the non-stretched portion (). Fluid is then injected through the bores of the hollow microneedles towards non-stretched portion.

System and method for delivering fluid into flexible biological barrier

A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles inserted into the biological barrier is generally sideways projecting from the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles project from a relief surface which is distinct from a primary biological-barrier contact region of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region is brought into contact with the biological barrier and moved parallel to the surface of the flexible biological barrier so as to generate a boundary between a stretched portion and a non-stretched portion of the barrier. Typically concurrently with this motion, the microneedles penetrate into the flexible biological barrier such that, at the end of the motion, the microneedles extend into the flexible biological barrier from the boundary region in a direction towards the non-stretched portion. Fluid is then injected through the bores of the hollow microneedles towards non-stretched portion.

A device () and method for transporting fluids across biological barriers enhances penetration of a biological barrier by the use of directional insertion, preferably with asymmetric microneedles () and/or microneedles () with sharp edges. Additionally, or alternatively, adhesion followed by alteration of contact geometry is employed to stretch the biological barrier across the microneedles (), thereby also enhancing penetration. Also disclosed is a device () and method which combine shallow penetration by hollow microneedles () with jet injection via the microneedles () to achieve a total liquid penetration depth greater than the mechanical penetration depth of the microneedles ().

Growing community of inventors

Nes Ziona, Israel

Yotam Levin