Toray Industries, Inc.

Other

Nanotheta Co., Ltd.

Waseda University

Jcr Pharmaceuticals Co., Ltd.

Toray University Educational System

Tokai University Educational System

Takeoka, Shinji

Yosuke Okamura

Shinji Takeoka

Toshinori Fujie

Saori Utsunomiya

Takahiro Goto

Toru Arakane

Motonori Hochi

Yuki Sekido

Yosuke Obata

Kohei Kubota

Yu Nagase

Takuya Komachi

Hideo Kanazawa

Shuji Hisamoto

Masanori Ohtsuka

Hong Zhang

Hiroshi Kimura

A polymer laminate has 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm that are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. A polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.

Polymer laminate

A method for preparing a thin film polymer structure having a functional substance on an A surface and a B surface of the film, the polymer structure being obtained by: (a) adsorbing polyfunctional molecules to a region of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then forming a soluble support film on the A surface; (d) exfoliating the thin film and the soluble support film from the substrate body; and (e) bonding to the B surface of the thin film a functional substance identical to or different from the functional substance bonded to the A surface and then dissolving the soluble support film with a solvent.

Thin film polymer structure having different modification on opposite sides thereof

A thin film polymer structure having a functional substance on the face (A surface) and reverse face (B surface) of the film, obtained by the steps of:

The present invention has an object of providing a drug carrier capable of controlling in vivo pharmacokinetics. The present invention is directed to a drug carrier comprising a molecular assembly having a drug incorporated therein, and the above object can be achieved by a part of the amphiphilic molecules included in the molecular assembly being released from the molecular assembly by an external environmental change. The present invention utilizes a phenomenon that the hydrophilic-hydrophobic balance of the amphiphilic molecules is shifted toward hydrophilicity by an external environmental change and thus the amphiphilic molecules are freed from the molecular assembly.

Drug carrier

Growing community of inventors

Chiba, Japan

Yosuke Okamura