Waseda University

Jcr Pharmaceuticals Co., Ltd.

Other

Kao Corporation

Yosuke Obata

Shinji Takeoka

Manabu Ito

Atsushi Mizuno

Takashi Kodate

Isao Sakane

Yosuke Okamura

Kohei Kubota

Hitoshi Kurumizaka

Shuji Hisamoto

Yoshito Takeuchi

Natsuko Nishiyama

Shoji Tajima

Syunsuke Saito

Namiko Ikegaya

Naoya Takeda

Hideo Kanazawa

The present invention relates to an adhesive sheet for cooling which preferably maintains a cooling effect utilizing the heat of vaporization of water and can exert a persistent high cooling effect. The adhesive sheet for cooling a hydrous polymer gel (A) and a fiber sheet (B) laminated thereon:

Adhesive sheet for cooling

The present invention has an object of providing a drug carrier capable of controlling in vivo pharmacokinetics. The present invention is directed to a drug carrier comprising a molecular assembly having a drug incorporated therein, and the above object can be achieved by a part of the amphiphilic molecules included in the molecular assembly being released from the molecular assembly by an external environmental change. The present invention utilizes a phenomenon that the hydrophilic-hydrophobic balance of the amphiphilic molecules is shifted toward hydrophilicity by an external environmental change and thus the amphiphilic molecules are freed from the molecular assembly.

Drug carrier

The present invention provides a reagent for introducing a protein or gene into a cell. The reagent of the present invention is, for example, a reagent for introducing a protein or gene into a cell, which comprises a composition comprising a cationic amino acid type lipid represented by the following formula (I)-1: (wherein in formula (I)-1: L is a single bond, &#x2014;CONH&#x2014;, or &#x2014;S&#x2014;S&#x2014;; Mis &#x2014;(CH)&#x2014; or &#x2014;(CHCHO)&#x2014; (wherein k is an integer between 0 and 14); and m1 and m2 are each independently an integer between 11 and 21 (in this regard, when providing a reagent for introducing a gene into a cell, the case where both m1 and m2 are 15 is excluded)).

Reagent for introduction of protein or gene

The present invention provides an amphiphilic molecule having a plurality of zwitterionic functional groups in its hydrophilic moiety and a molecular assembly comprising the amphiphilic molecule as a constituent lipid. The molecular assembly of the present invention forms a stable vesicular structure under a physiological pH environment to carry a substance of interest in the vesicular structure, and can release the substance of interest to the outside of the vesicular structure when it is deformed under an acidic pH environment. The molecular assembly of the present invention can be used as a carrier for a drug, a probe, a nucleic acid, a protein or the like.

Amphiphilic molecule, molecular assembly comprising the amphiphilic molecule, and use of the molecular assembly

The present invention provides a novel complex lipid having a cationic functional group derived from an amino acid. Namely, the present invention provides a cationic acid amino acid type lipid represented by the following formula: wherein, Ris a hydrocarbon group having a cationic functional group derived from an amino acid, Rand Rare each independently a chain hydrocarbon group, Aand Aare each independently a linkage group selected from the group consisting of &#x2014;COO&#x2014;, &#x2014;OCO&#x2014;, &#x2014;CONH&#x2014; and NHCO&#x2014;, and n is an integer of 2 to 4.

Cationic amino acid type lipid

Growing community of inventors

Tokyo, Japan

Yosuke Obata